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CPR > Autonomic Pharmacology > Flashcards

Autonomic Pharmacology Flashcards

1
Q

What are the main neurotransmitters used in the sympathetic system?

A

Ach, NE, Epi and Dopamine (DA)

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2
Q

What are the main neurotransmitters used in the parasympathetic system?

A

Ach

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3
Q

What are the main receptors used in the sympathetic system?

A

nAchR
mAchR
Alpha and Beta Adrenergic

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4
Q

What are the main receptors used in the parasympathetic system?

A

nAchR

mAchR

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5
Q

Transmission that involves the release of Ach

A

Cholinergic

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6
Q

Transmission that involves the release of catecholamines

A

Adrenergic

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7
Q

Catecholamines

A

NE (norepinephrine)
Epinephrine
Dopamine

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8
Q

Every pre-ganglionic fiber (sympathetic and parasymptahetic) releases ____ to a _____ receptor

A

Ach

nAchR

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9
Q

Post-ganglionic parasympathetic fibers release what to what receptors?

A

Ach to mAchR

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10
Q

Post-ganglionic sympathetic fibers that release Ach to mAchr, innervate what?

A

Sweat glands

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11
Q

Post-ganglionic sympathetic fibers that release NE, release it to what receptors?

A

Alpha and Beta Adrenergic

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12
Q

Post-ganglionic sympathetic fibers that release DA, release it to what receptors?

A

D1 - D5

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13
Q

Where is a majority of the Epi released from?

A

Adrenal Medulla

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14
Q

What neurotransmitter binding to what receptor activates the release of NE and Epi from the adrenal medulla

A

Ach to nAchR

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15
Q

What does dopamine innervate?

A

Renal vasculature and smooth muscle

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16
Q

What is the cascade of cholinergic transmission steps?

A

Ach synthesis
Ach storage
Ach release
Ach degradation

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17
Q

What degrades Ach?

A

Acetylcholinesterase

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18
Q

What type of receptor is nAchR?

A

Ionotropic - N+/K+ channel

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19
Q

What type of receptor is mAchR?

A

Metabotropic - G protein

20
Q

Ionotropic receptors are _____

A

Excitatory

21
Q

Metabotropic receptors are ______ and _____

A

Excitatory and inhibitory

22
Q

Which mAchR receptors used Gq/11 to signal?

A

M1, M3, M5

23
Q

Which mAchR receptors use Gi/o to signal?

A

M2, M4

24
Q

What is the cascade of adrenergic transmission steps?

A

Synthesis
Storage
Release
REUPTAKE

25
Q

How are adrenergic signals terminated?

A

NT REUPTAKE

26
Q

In order to create catecholamines in the cell, what AA enters?

A

Tyrosine

27
Q

Describe the order of catecholamines made in the cell

A 
Tyrosine
Dopa
Dopamine
*Enters vesicle*
NE
28
Q

What transports catecholamines into vesicles?

A

VMAT-2

29
Q

What transports NE back into the cell (reuptake)?

A

NET

30
Q

What transports DA back into the cell (reuptake)?

A

DAT

31
Q

In general, what receptors cause vasoconstriction?

A

Alpha1

32
Q

In general, what receptors cause vasodilation?

A

Beta2

33
Q

Blood vessels are innervated by _____ receptors

A

Adrenergic

34
Q

Are blood vessels innervated by parasympathetics?

A

NO

35
Q

What receptors will you not find in blood vessels?

A

nAchR

mAchR

36
Q

Stimulation of the receptors on a blood vessel will cause?

A

Vasoconstriction

37
Q

What must be intact for a blood vessel to vasodilate?

A

Endothelium

38
Q

Describe how a blood vessel can vasodilate if Ach is released to an endothelial cell?

A

Ach binds to a mAchR
Activates the release of NO
NO goes to the smooth muscle cell and relaxes it

39
Q

What vasodilates blood vessels?

A

Nitric Oxide released from endothelial cells after Ach binds

40
Q

Activates a receptor

A

Agonists

41
Q

Blocks a receptor from being activated

A

Antagonists

42
Q

Cholinomimetic agents

A

Mimic Ach - agonists

43
Q

Cholinoreceptor - blocking drugs

A

AchR antagonists

44
Q

Sympathomimetic agents

A

Mimic catecholamines - agonists

45
Q

What will Sympathomimetic agonists block?

A

REUPTAKE

46
Q

Adrenoreceptor - blocking drugs

A

Alpha/beta receptor antagonists

47
Q

Muscarinic receptor activation causes?

A

Contraction

CPR (48 decks)

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