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POSITIVE SENSE RNA (NAKED) Flashcards

1
Q
A
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2
Q

POSITIVE-SENSE

NAKED VIRUSES

A

Calcivirus
Hepevirus
Picornavirus

CHiP

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3
Q

POSITIVE SENSE | NAKED

  • Very large virus family
  • Smallest size
  • Sensitive to acidic environment
  • labile, grows at 33C
  • Virion: icosahedral
  • Composition: RNA 30%, protein 70%
  • Replication: cytoplasm
  • Two major groups of human pathogens
    o Enterovirus
    o Rhinovirus
A

PICORNA VIRUSES

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4
Q

PICORNA VIRUSES

____ virus family

A

very large

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5
Q

PICORNA VIRUSES

size

A

smallest

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6
Q

PICORNA VIRUSES

virion

A

icosahedral

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7
Q

PICORNA VIRUSES

composition

A

RNA 30%
protein 70%

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8
Q

PICORNA VIRUSES

replication

A

cytoplasm

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9
Q

PICORNA VIRUSES

sensitive to ____ environment

A

acidic

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10
Q

PICORNA VIRUSES

two major groups of human pathogen

A

enterovirus
rhinovirus

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11
Q

PICORNA VIRUSES | ENTEROVIRUS

  • have a very restricted host range (primates)
  • Three antigenic types – VP1, VP2, VP3 proteins
  • Portal of entry – mouth
  • Site of replication – oropharynx or intestine
  • Incubation period – 7 to 14 days
  • Most infections are subclinical
A

POLIOVIRUS

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12
Q

POLIOVIRUS

under what group of PICORNA virus

A

enterovirus

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12
Q

POLIOVIRUS

have a ____ host range

A

very restricted

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13
Q

POLIOVIRUS

host range

A

primates

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14
Q

POLIOVIRUS

three antigenic types

A

VP1
VP2
VP3

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15
Q

POLIOVIRUS

portal of entry

A

mouth

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16
Q

POLIOVIRUS

site of replication

A

oropharynx or intestine

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16
Q

POLIOVIRUS

most infections are ____

A

subclinical

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16
Q

POLIOVIRUS | TREATMENT & PREVENTION

drugs

A

no antiviral drugs, treatment is symptomatic

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16
Q

POLIOVIRUS

incubation period

A

7 - 14 days

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17
Q

POLIOVIRUS | CLINICAL FINDINGS

decreasing size of muscle due to aging ; not because of the virus

A

Progressive postpoliomyelitis muscle atrophy

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17
Q

POLIOVIRUS | CLINICAL FINDINGS

fever, malaise, drowsiness, headache, N&V, and sore throat

A

MILD DISEASE (ABORTIVE POLIOMYELITIS)

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17
Q

POLIOVIRUS | CLINICAL FINDINGS

aseptic meningitis

A

nonparalytic poliomyelitis

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17
Q

POLIOVIRUS | CLINICAL FINDINGS

flaccid paralysis resulting from lower motor neuron damage
▪ Memingoencephalitis, meningomyeloencephallitis

A

paralytic poliomyelitis

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# **POLIOVIRUS | TREATMENT & PREVENTION** PREVENTION: **Live** attenuated vaccine
Sa**b**in vaccine Oral vaccine, OPV | b - buhay
17
# **POLIOVIRUS | TREATMENT & PREVENTION** PREVENTION: **Killed** vaccine
Sal**k** vaccine Inactivated vaccine, IPV | k - killed
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**Coxsackie** virus is under what **group** of **PICORNA** virus
enterovirus
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# **COXSACKIEVIRUS** originated from what **place**
Coxsackie new york
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# **COXSACKIEVIRUS | GROUP A** transmission
fecal oral route
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# **COXSACKIEVIRUS** * Transmission – **fecal oral route** * Herpangina (types **2 – 6, 8, 10**) – **severe febrile pharyngitis** * **Diarrhea** in **children**
GROUP A
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# **COXSACKIEVIRUS | GROUP A** severe febrile pharyngitis
Herpangina types 2-6, 8, 10
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# **COXSACKIEVIRUS** * **Pleurodynia** * **Myocarditis and pericarditis** (types 1 – 5) * **Generalized disease of infants** (types 1 – 5)
GROUP B
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# **COXSACKIEVIRUS | GROUP A** diseases
Herpangina Diarrhea in children
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# **COXSACKIEVIRUS | GROUP A** disease in **children**
diarrhea
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# **COXSACKIEVIRUS** * can cause **flaccid paralysis** * **Aseptic meningitis** * **Hand-foot-and-mouth** disease
GROUP A & B
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# **COXSACKIEVIRUS | GROUP A & B** **hand**, **foot** and **mouth** disease
types A5, 10, 160
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# **COXSACKIEVIRUS | GROUP B** **MYOCARDITIS** & **PERICARDITIS**
types 1 - 5
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# **COXSACKIEVIRUS | GROUP B** characterized by **simultaneous viral infections** of **multiple organs**, including the **heart**, **liver**, and **brain**
generalized disease of infants
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# **COXSACKIEVIRUS | GROUP A & B** **aseptic meningitis**
types A7 & A9; type B
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# **COXSACKIEVIRUS | GROUP B** **generalized** disease of **infants**
types 1 - 5
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# **COXSACKIEVIRUS | GROUP A & B** characterized by **fever**, **malaise**, **headache**, **nausea**, and **abdominal pain**
aseptic meningits
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# **PICORNA VIRUS | ENTEROVIRUS** * Enteric Cytopathogenic Human Orphan Viruses * Transmission – **fecal oral** * Diseases – **aseptic meningitis**, **encephalitis**, **febrile illness with or without rash**, **common colds**, **ocular disease**
ECHOVIRUS
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# **COXSACKIEVIRUS | GROUP A & B** characterized by **oral** and **pharyngeal ulcerations** and a **vesicular rash** of the **palms** and **soles**
hand, foot, and mouth disease
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# **ECHOVIRUS** is under what **group** of **PICORNA** virus
enterovirus
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# **ECHOVIRUS** meaning of ECHO
Enteric Cytopathogenic Human Orphan Viruses
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# **OTHER ECHOVIRUS** **acute hemorrhagic conjunctivitis**
ENTEROVIRUS 70
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# **ECHOVIRUS** transmission
fecal oral
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# **OTHER ECHOVIRUS** **meningitis**, **encephalitis**, and **paralysis resembling poliomyelitis**, **hand-foot-and-mouth disease**
ENTEROVIRUS 71
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# **OTHER ECHOVIRUS** **Hepatitis** **A** virus
ENTEROVIRUS 72
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# **ECHOVIRUS** **leading cause** of ____
aseptic meningitis
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# **RHINOVIRUS** ____ labile
acid
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# **PICORNA VIRUS** * **Common cold** virus * **Acid**-labile * Temperature requirement: **33C** * Transmission – **sneezing**, **hand-to-hand**, **hand-to-eye**, or **hand-to-object-to-hand** * The virus **enters** via **URT**, and **replicates** in the **nasal mucosa** * Incubation – **2 to 4 days** * Usual symptoms in **adults** – **sneezing**, **nasal obstruction**, **nasal discharge**, and **sore throat** * Other symptoms – **headache**, **mild cough**, **malaise**, and a **chilly sensation** * **Other viruses** causing URT infections – **coronavirus**, **adenovirus**, **enterovirus**, **parainfluenza virus**, **influenza virus**
RHINOVIRUS
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# **RHINOVIRUS** portal of **entry**
URT
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# **RHINOVIRUS** ____ virus
common cold
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# **RHINOVIRUS** **temperature** requirement
33C
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# **RHINOVIRUS** **replication** site
nasal mucosa
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# **RHINOVIRUS** Usual symptoms in **adults**
sneezing nasal obstruction nasal discharge sore throat
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# **RHINOVIRUS** incubation
2 - 4 days
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# **RHINOVIRUS** other symptoms
headache mild cough malaise chilly sensation
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# **CALCIVIRUS** **Norovirus** ____ communicable
highly
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# **RHINOVIRUS** **other viruses** causing URT infections
corona adeno enetero parainfluenza influenza
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# **PICORNA VIRUS** * **Norovirus** * **Sapovirus** * **Nebovirus** * **Lagovirus** * **Vesivirus**
CALCIVIRUS
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# **CALCIVIRUS** NOROVIRUS: **infectious dose**
10 viral particles
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# **CALCIVIRUS** **Sapporo-like** virus
Sapovirus
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# **CALCIVIRUS** **Bovine enteric** virus
Nebovirus
30
# **CALCIVIRUS** **rabbit hemorrhagic disease** virus
Lagovirus
31
# **CALCIVIRUS** **vesicular exanthem** virus
Vesivirus

MICROPARA (37 decks)

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