M7 DNA VIRUS | NAKED Flashcards
1
Q
DNA NAKED viruses
A
Adenovirus
Papillomavirus
Polyomavirus
2
Q
symmetry of ALL naked DNA viruses
A
icosahedral
3
Q
NAKED
- only virus that has fibers
- Virion – icosahedral, 70-90 nm in diameter, 252 capsomeres; fiber projects from each vertex
- Composition – DNA (13%), protein (87%)
- Genome – double-stranded DNA, linear, 26-45 kbp, protein bound to termini, infectious
- Proteins – important antigens (hexon, penton base, fiber) are associated with the major outer capsid proteins
- Envelope – none
- Replication – nucleus
- Outstanding characteristic – excellent models for molecular studies of eukaryotic cell processes
A
ADENOVIRUS
4
Q
ADENOVIRUS
VIRION:
symmetry
A
icosahedral
5
Q
ADENOVIRUS
VIRION:
size
A
70-90nm diameter
6
Q
ADENOVIRUS
VIRION:
capsomeres
A
252
7
Q
ADENOVIRUS
composition
A
DNA 13%
protein 87%
8
Q
ADENOVIRUS
PROTEINS:
important antigens
A
hexon, penton base, fiber
9
Q
ADENOVIRUS
important antigens (hexon, penton base, fiber) are associated with the ____
A
major outer capsid proteins
10
Q
ADENOVIRUS
replication
A
nucleus
11
Q
ADENOVIRUS
excellent models for molecular studies of ____
A
eukaryotic cell processes
12
Q
ADENOVIRUS
isolated in the ____
A
adenoin
13
Q
ADENOVIRUS
GROUP C
A
1, 2, 5, 6, 57,
14
Q
ADENOVIRUS
can establish latent infection in adenoid tissue & tonsils
A
GROUP C
1, 2, 5, 6, 57
15
Q
ADENOVIRUS
GROUP C can establish latent infections in
A
adenoid tissue & tonsils
16
Q
ADENOVIRUS | CLINICAL FINDINGS
RESPIRATORY DISEASE:
Acute RTI in young children
A
types 1, 2, 5, 6
17
Q
ADENOVIRUS | CLINICAL FINDINGS
RESPIRATORY DISEASE:
Acute RTI in adolescents and adults
A
types 3, 4, 7
18
Q
ADENOVIRUS | CLINICAL FINDINGS
respiratory diseases can lead to
A
pneumonia
19
Q
ADENOVIRUS | CLINICAL FINDINGS
RESPIRATORY DISEASE:
10 to 20% childhood pneumonia
A
types 3, 7, 21
20
Q
ADENOVIRUS | CLINICAL FINDINGS
RESPIRATORY DISEASE:
____ to ____% childhood pneumonia
A
10 to 20%
21
Q
ADENOVIRUS | CLINICAL FINDINGS
RESPIRATORY DISEASE:
Outbreak of severe respiratory disease in 2007 (all ages)
A
type 14
22
Q
ADENOVIRUS | CLINICAL FINDINGS
RESPIRATORY DISEASE:
Acute respiratory disease syndrome among military recruits
A
types 3, 4, 7
23
Q
ADENOVIRUS | CLINICAL FINDINGS
RESPIRATORY DISEASE:
among military recruits
A
acute respiratory disease syndrome
24
Q
ADENOVIRUS | CLINICAL FINDINGS
DISEASES
A
respiratory
eye
GI
25
# **ADENOVIRUS | CLINICAL FINDINGS | EYE INFECTIONS**
**Mild ocular involvement** maybe part of the ____
RESPIRATORY PHARYNGEAL SYNDROMES
26
# **ADENOVIRUS | CLINICAL FINDINGS | EYE INFECTIONS**
“**Swimming pool conjunctivitis**” in **children**
types 3, 7
27
# **ADENOVIRUS | CLINICAL FINDINGS | EYE INFECTIONS**
**Epidemic** and **highly contagious** keratoconjunctivitis in **adults**
types 8, 9, 37
28
# **ADENOVIRUS | CLINICAL FINDINGS**
Brought about by the **replication of the virus** in the **intestinal cells** and their **presence in stools**
GASTROINTESTINAL DISEASES
29
29
# **ADENOVIRUS | CLINICAL FINDINGS | GASTROINTESTINAL DISEASES**
a **viral gastroenteritis** in **young children** manifested as **diarrhea**
INFANTILE GASTROENTERITIS
30
# **ADENOVIRUS | CLINICAL FINDINGS | GASTROINTESTINAL DISEASES**
“**Infantile gastroenteritis**” a viral gastroenteritis in young children manifested as diarrhea
type 40, 41
31
# **ADENOVIRUS | CLINICAL FINDINGS | OTHER DISEASES (IMMUNOCOMPROMISED)**
**Respiratory** disease that **progresses** to **severe** and **fatal pneumonia** among **transplant** patients
types 1 - 7
32
# **ADENOVIRUS | CLINICAL FINDINGS | OTHER DISEASES (IMMUNOCOMPROMISED)**
in **children**
**kidney** & **bone marrow** transplant patients
acute hemorrhagic cystitis
33
# **ADENOVIRUS | TREATMENT**
DOC
no specific treatment
34
# **ADENOVIRUS | TREATMENT**
**Live** adenovirus **vaccine**
types 4, 7
35
# **ADENOVIRUS | TREATMENT**
* administered **orally** as a **capsule**
* **reserved** for **military**
Live adenovirus vaccine
36
# **NAKED**
* **Small** viruses with **circular genome**
* It contains genes that **code for T (tumor) antigen**, **inhibiting p53** and **Rb**
HUMAN POLYOMA VIRUS
37
# **HUMAN POLYOMA VIRUS**
**small** viruses with ____ **genome**
circular
38
# **HUMAN POLYOMA VIRUS**
it **contains** genes that **code** for ____ antigen, **inhibiting p53** and **Rb**
T (tumor)
39
# **HUMAN POLYOMA VIRUS**
**p53** and **Rb** are
tumor suppressor gene
40
# **HUMAN POLYOMA VIRUS**
* **kidney**
* causes **hemorrhagic cystitis** and **polyomavirus-associated nephropathy**
* among **transplant** patients
BK virus
41
# **HUMAN POLYOMA VIRUS**
* **brain**
* causes progressive **multifocal leukoencephalopathy**
JC virus
42
# **HUMAN POLYOMA VIRUS**
* occurred in **nasopharyngeal** aspirates in **children** with respiratory infections
* patients with **existing** respiratory infections
KI and WU viruses
43
# **HUMAN POLYOMA VIRUS**
* **face**, **neck**
* associated with **Merkel-cell carcinoma**, a **rare skin tumor** of **neuroendocrine** origin
* **aggressive**
MERKEL CELL virus
44
# **HUMAN POLYOMA VIRUS**
* **transmission** by **close contact**;
* **carcinogenesis** involves **synthesis** of viral proteins **E6** and **E7** that **interfere** with the activity, **p53** and **Rb**
WARTS virus
45
# **HUMAN POLYOMA VIRUS | WARTS VIRUS**
transmission by
CLOSE CONTACT
46
# **HUMAN POLYOMA VIRUS | WARTS VIRUS**
____ involves **synthesis of viral proteins** E6 and E7 that **interfere** with the activity, p53 and Rb
CARCINOGENESIS
47
# **HUMAN POLYOMA VIRUS | WARTS VIRUS**
**carcinogenesis** involves **synthesis of viral proteins** ____ and ____ that **interfere** with the activity, p53 and Rb
E6, E7
48
# **HUMAN POLYOMA VIRUS | PREVENTION & CONTROL**
for **cervical cancer**
| early detection
Papanicolaou (Pap) smear
49
# **HUMAN POLYOMA VIRUS | PREVENTION & CONTROL**
vaccine
HPV vaccine
GARDASIL 9
| also associated w/ **oral pharyngeal cancer**
50
# **HUMAN POLYOMA VIRUS | TYPE**
**recurrent** **respiratory** papillomatis
type 6, 11
51
# **HUMAN POLYOMA VIRUS | TYPE**
responsible for **cervical cancer**
type 16, 18
52
# **NAKED**
* the **ONLY single stranded** DNA virus
* **Smallest** DNA **animal** viruses
* Transmission – **respiratory** route, **blood** transfusions, and **vertically**
PARVOVIRUS
53
# **PARVOVIRUS**
the **only** ____ DNA virus
single stranded
54
# **PARVOVIRUS**
* **pathogenic** for **humans** and has a **tropism** for **erythroid progenitor cells**
* **targets EPC** where **RBC forms**
PARVOVIRUS B19
55
# **PARVOVIRUS**
transmission
respiratory
blood
vertically
56
# **PARVOVIRUS**
replication
nucleus
57
# **PARVOVIRUS**
targets mainly ____
RBC production
58
# **PARVOVIRUS | HUMAN DISEASES**
* HOST: **Children** (**Fifth disease**), **Adults**
* CLINICAL FEATURE: **cutaneous rash** (**slapped cheeck syndrome**), **arthralgia** -- **arthirits**
ERYTHEMA INFECTIOSUM
59
# **PARVOVIRUS | HUMAN DISEASES**
also known as **Fifth disease**
Erythema infectiosum
60
# **PARVOVIRUS | HUMAN DISEASES**
**cutaneous rash** in **erythema infectiosum** is also known as
slapped cheek syndrome
61
# **PARVOVIRUS | HUMAN DISEASES**
* CONDITION: **underlying hemolysis**
* CLINICAL FEATURE: **severe acute anemia**
* **stops** the **synthesis** of **RBC**
TRANSIENT APLASTIC CRISIS
62
# **PARVOVIRUS | HUMAN DISEASES**
* CONDITION: **immunodeficiencies**
* CLINICAL FEATURE: **chronic anemia**
PURE RED CELL APLASIA
63
# **PARVOVIRUS | HUMAN DISEASES**
* HOST: **fetus**
* CLINICAL FEATURE: **fatal anemia**
HYDROPS FETALIS
64
# **PARVOVIRUS | HUMAN DISEASES**
* **Fifth** disease – “**Slapped Cheek Syndrome**”
* Characterized by **fever** and **bright red rash** on the **cheeks**
* A **lace-like rash** on the **body** may appear on the body (in adults)
* It **mimics** **rheumatoid arthritis** in **adults**
* **Symptomatic** treatment
ERYTHEMA INFECTIOSUM
65
# **PARVOVIRUS | HUMAN DISEASES | ERYTHEMA INFECTIOSUM**
a **rash** that may **appear** on the **body** of **adults**
lace like rash
66
# **PARVOVIRUS | HUMAN DISEASES | ERYTHEMA INFECTIOSUM**
it **mimics** ____ in **adults**
rheumatoid arthritis
67
# **PARVOVIRUS | HUMAN DISEASES | ERYTHEMA INFECTIOSUM**
treatment
symptomatic
68
# **PARVOVIRUS | HUMAN DISEASES**
* The syndrome is an **abrupt cessation of RBC synthesis** in the **bone marrow**
* **sudden stop** of RBC synthesis
* Individuals with **chronic hemolytic anemia**, such as patients with **sickle cell disease**, **thalassemia**, and **acquired hemolytic anemias** in adults are **susceptible** (only with patients with exisiting condition)
* **Symptomatic** treatment
TRANSIENT APLASTIC CRISIS
69
# **PARVOVIRUS | HUMAN DISEASES | TRANSIENT APLASTIC CRISIS**
The syndrome is an **abrupt** ____ in the **bone marrow**
CESSATION OF RBC SYNTHESIS
70
# **PARVOVIRUS | HUMAN DISEASES | TRANSIENT APLASTIC CRISIS**
The syndrome is an a**brupt cessation of RBC synthesis** in ____
BONE MARROW
71
# **PARVOVIRUS | HUMAN DISEASES | TRANSIENT APLASTIC CRISIS**
treatment
symptomatic
72
# **PARVOVIRUS | HUMAN DISEASES**
* **Pure red cell aplasia**
* It has been observed in patient populations with **congenital immunodeficiency**, **malignancies**, **AIDS**, and **organ transplantation**
B19 INFECTION IN **IMMUNODEFICIENT** PATIENTS
73
# **PARVOVIRUS | HUMAN DISEASES | B19 INFECTION IN IMMUNODEFICIENT**
it is characterized by **chronic suppression** of **bone marrow**
PURE RED CELL APLASIA
74
# **PARVOVIRUS | HUMAN DISEASES | B19 INFECTION DURING PREGNANCY**
**1st** trimester
**fetal death** due to **severe anemia**
75
# **PARVOVIRUS | HUMAN DISEASES | B19 INFECTION DURING PREGNANCY**
* **2nd** trimester
* **swelling of organs**
hydrops fetalis
76
# **PARVOVIRUS**
**Parvovirus B19** is pathogenic for humans and **has a tropism** for ____
erytheroid progenitor cells
