ANTIVIRAL AGENTSA

Question 1

mimics guanine

Answer 1

acyclovir
ganciclovir
idoxuridine
trifluridine

Question 2

Herpes is a ____ virus

Answer 2

DNA

Question 3

common mechanism of action of drugs for DNA viruses

Answer 3

inhibition of DNA replication

Question 4

viruses with ANTIVIRAL AGENTS

Answer 4

Herpes
Hepatitis B & C
HIV
Influenza

Question 5

• Well tolerated and causes few side effects
• may cause renal or central nervous system toxicity
• Genital herpes, chicken pox, shingles

Answer 5

acyclovir

Question 6

Achieves a high plasma concentration when taken orally and is used in herpes

Answer 6

valacyclovir

Question 7

• Side effect – leukopenia and thrombocytopenia as a result of bone marrow suppression
• Cytomegalovirus retinitis

Answer 7

Ganciclovir

Question 8

• Side effect – kidney damage
• CMV retinitis and severe HPV

Answer 8

cidofovir

Question 9

• Toxic to be used systematically
• Keratitis caused by herpes virus infection

Answer 9

idoxuridine
trifluridine

Question 10

• Renal impairment, hypo- or hypercalcemia, hypo- or hyperphosphatemia, hypokalemia, and hypomagnesemia
• Retinitis caused by herpes virus infection

Answer 10

foscarnet

Question 11

drugs are formulated with the ability to resemble the ____ and make them nonfunctional

Answer 11

nucleoside

Question 12

blocks the 1st step in DNA repli

Answer 12

acyclovir
penciclovir
ganciclovir

Question 13

blocks the 2nd step in DNA repli

Answer 13

trifluridine
cidoflovir

Question 14

blocks the 3rd step in DNA repli

Answer 14

foscarnet

Question 15

NUCLEOSIDE REVERSE TRANCRIPTASE INHIBITORS

Answer 15

Didanosine
Abacavir
Zidovudine
Zalcitabine
Lamivudine
Emtricitabine
Tenofovir
Stavudine

DAZZLETS

Question 16

NON NUCLEOSIDE REVERSE TRASNCRIPTASE inhibitors

Answer 16

all with VIR in the middle
Delavirdine
Efavirenz
Etravirine
Nevirapine

Question 17

PROTEASE inhibitors

Answer 17

all with VIR at the end
Atazanavir
Darunavir
Fosamprenavir
Indinavir
Lopinavir
Ritonavir

Question 18

ENTRY INHIBITORS

Answer 18

Enfuvirtide
Maraviroc

Question 19

INTEGRASE INHIBITORS

Answer 19

Raltegravir

Question 20

Protease inhibitors are usually administered by ____

Answer 20

combination with NRT

Question 21

• exemption for protease inhibitors
• administered in combination with another protese inhibitor

Answer 21

ritonavir

Question 22

side effect of protease inhibitors

Answer 22

fat accumulation at the back of the neck

Question 23

protease inhibitor side effect presents ____ appearance

Answer 23

buffalo hump

Question 24

reduce viral load and elevate CD4+ levels

Answer 24

Lami + Zido

Question 25

for **Hepa B chronic** infections

Answer 25

Lami

Question 26

* for patients who developed **resistance against other NRT inhibitors** * also used for **first time treatments**

Answer 26

Tenofovir

Question 27

# **ANTI-HEPATITIS** **first** line drugs

Answer 27

Adefovir (Hespera) Enetecavir (Baraclude)

Question 28

# **ANTI-HEPATITIS** * nucleotide analogue of **AMP** * **inhibits DNA polymerase**

Answer 28

adefovir (hepsera)

Question 29

# **ANTI-HEPATITIS** **guanosine** analogue that **inhibits DNA polymerase**

Answer 29

enetecavir (baraclude)

Question 30

# **ANTI-HEPATITIS** NRT inhibitors

Answer 30

Lami & Teno

Question 31

# **ANTI-HEPATITIS** interferon alfa that is used because of **longer duration of action**

Answer 31

pregylated interferon alfa

Question 32

# **ANTI-HEPATITIS** mimics **guanine**

Answer 32

ribavirin

Question 33

# **ANTI-INFLUENZA** **no longer used** because of resistamnce

Answer 33

amantadine

Question 34

# **ANTI-INFLUENZA** blocks viral **uncoating**

Answer 34

amantadine rimantadine

Question 35

# **ANTI-INFLUENZA** **neuraminidase inhibitors**

Answer 35

oseltamivir (tamiflu) zanamivir (relenza)