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M5 PART 11 Flashcards

1
Q
  • Obligate intracellular parasites
  • Vector borne
  • Pleomorphic coccobacilli
A

RICKETTSIA

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2
Q

RICKETTSIA

VISIBLE UNDER WHAT STAINS

A

Giemsa stain
Gimenez stain
Acridine orange

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3
Q

RICKETTSIA

grow readily in ____

A

yolk sacs of embryonated eggs

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4
Q

RICKETTSIA | ANTIGENIC STRUCTURES

contain ____ and cell wall surface protein ____ and ____

A

LPS
OmpA
Ompb

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5
Q

RICKETTSIA | ANTIGENIC STRUCTURES

These surface proteins are important in adherence to host cells and in the humoral immune response and also provide the basis of serotyping

A

OmpA
OmpB

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6
Q

RICKETTSIA

  • measures the presence of antirickettsial antibodies
  • Serum antibody will be agglutinated
A

WIEL FELIX TEST

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7
Q

RICKETTSIA | PATHOLOGY

Multiply in ____ of small blood vessels and produce vasculitis characterized by lymphocytes that surround the blood vessels

A

ENDOTHELIAL CELLS

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8
Q

RICKETTSIA | PATHOLOGY

Vasculitis lesions are prominent in the ____

A

skin

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9
Q

characterized by fever, headache, malaise, prostration, skin rash, and enlargement of the spleen and liver.

A

RICKETTSIA

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10
Q

RICKETTSIA PROWAZEKII

VECTOR

A

BODY LOUSE

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11
Q

RICKETTSIA PROWAZEKII

RESERVOIR

A

HUMANS

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12
Q

RICKETTSIA PROWAZEKII | DISEASES

  • systemic infection and prostration are severe and fever lasts for about 2 weeks.
  • The disease is more severe and more fatal in patients older than 40 years of age.
  • During epidemics, the case fatality rate has been 6 – 30%
A

Epidemic typhus (louse born typhus)

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13
Q

RICKETTSIA PROWAZEKII | DISEASES

  • recurrence of an old typhus
  • can reccur as long as 50 years later
  • Milder
  • Reactivated form of epidemic typhus (organism entered a stage of latency → reactivate)
A

Brill-Zinsser disease

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14
Q

common clinical manifestation in RICKETTSIA

A

RASHES

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15
Q

RICKETTSIA TYPHII

vector

A

FLEA

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16
Q

RICKETTSIA TYPHII

RESERVOIR

A

RODENTS

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17
Q

milder than epidemic typhus
fatal for elderly

A

RICKETTSIA TYPHII

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18
Q

RICKETTSIA TYPHII | DISEASES

Has many clinical features in common with that of epidemic typhus, but the disease is milder and is rarely fatal except in elderly patients

A

endemic typhus (flea-borne typhus) or
murine typhus

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19
Q
  • fever, chills, myalgia, headache, rash (no eschar);
  • milder illness than epidemic typhus
A

RICKETTSIA TYPHII

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20
Q

RICKETTSIA RICKETSII

vector

A

ticks

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21
Q

RICKETTSIA RICKETSII

reservoir

A

rodents
dogs

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22
Q

RICKETTSIA RICKETSII

disease

A

rocky mountain spotted fever

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23
Q

RICKETTSIA RICKETSII | DISEASE

Inward appearance of pustules
extremitis → inward to trunk → palm & soles

A

Rocky Mountain spotted fever (RMSF)

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24
Q
  • fever, HA, rash (no eschar); many systemic manifestation (hemorrhage, pulmonary edema)
  • Higher mortality rate
  • occur 3-5 days after the illness
  • life threatening for all age groups
A

RICKETTSIA RICKETSII

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25
# **RICKETTSIA AKARI** vector
mites
26
# **RICKETTSIA AKARI** reservoir
mice
27
# **RICKETTSIA AKARI** disease
rickettsial pox
28
# **RICKETTSIA AKARI** * **Mild** disease with a **vesicular** rash **resembling** that of **varicella** * **Resembles chicken pox** * About 1 week before onset of fever, a firm red papule appears at the site of the mite and develops into a deep-seated vesicle that in turn **forms a black eschar**
RICKETTSIAL POX
29
**mild** illness, fever, headache, **vesicular** **rash (eschar)**
RICKETTSIA AKARI Rickettsial pox
30
# **ORIENTIA TSUTSUGAMUSHI** vector
mites
31
# **ORIENTIA TSUTSUGAMUSHI** reservoir
rodents
32
# **ORIENTIA TSUTSUGAMUSHI** disease
scrub typhus
33
# **ORIENTIA TSUTSUGAMUSHI** * Fever, headache, rash, **lymphadenopathy**, **atypical lymphocytes** * One feature is the **eschar**, the **punched-out ulcer** covered with a **blackened scab** that indicates the location of the mite bite
Scrub typhus
34
fever, headache, **rash (50% have eschar)**, **lymphadenopathy**, **atypical lymphocytes**
ORIENTIA TSUTSUGAMUSHI Scrub typhus
35
# **ORIENTIA TSUTSUGAMUSHI** DRUG OF CHOICE
doxycycline
36
# **ORIENTIA TSUTSUGAMUSHI** can **enhance** the disease and are **contraindicated**
SULFONAMIDES
37
# **COXIELLA BURNETII** STAIN
Gimenez
38
# **COXIELLA BURNETII** **resistant** to
**drying** may survive pasteurization
39
# **COXIELLA BURNETII** TRANSMISSION
inhalation of aerosol
40
* **Small obligate** organisms that have a membrane **similar** to gram **negative** bacteria * grows in **cytoplasmic vacuoles** * Stains with **Gimenez** * **Resistant to drying** and **may survive pasteurization** at 60 deg C for 30 minutes * Transmission is via **inhalation of aerosol** * Vector transmission: only possible in aqnimals
COXIELLA BURNETII
41
# **COXIELLA BURNETII | PHASES** * **virulent form** found in humans with **Q fever** and in infected vertebrate animals * **LPS** is expressed
PHASE I
42
# **COXIELLA BURNETII | PHASES** * **not infectious** and occur only by **seria passage** in cell cultures * the MO **lost its ability** to **synthesize** the antigen used for infections
PHASE II
43
# **COXIELLA BURNETII** disease
Q FEVER
44
# **COXIELLA BURNETII | DISEASE** * **resembles influenza** * **non**bacterial **pneumonia** and **hepatitis** * **recovery** is **possible**
ACUTE DISEASE
45
# **COXIELLA BURNETII | DISEASE** * **infective endocarditis** is the **most common form** of disease in this phase * lasts for **more than 6 months** * **rarely** occurs
CHRONIC DISEASE
46
# **COXIELLA BURNETII** DRUG OF CHOICE
doxycycline
47
* **Obligate intracellular** bacteria * Their **cell wall is rigid**, but **do not have a typical peptidoglycan layer** because it **lacks muramic acid**. * **MOMP** is an **important structural component** peptidoglycan – N-acetyl, glucosamine, N-acetyl muramic acid, major outer membrane protein
CHLAMYDIA
48
# **CHLAMYDIA** **Lacks** ____ in peptidoglycan
MURAMIC ACID
49
# **CHLAMYDIA** used for **adhesion**
MOMP
50
# **CHLAMYDIA** **All** chlamydia possesses ____
shared group specific antigen
51
# **CHLAMYDIA TRACHOMATIS** DISEASE: **TRACHOMA** Clinical presentation: ____
CHRONIC KERATOCONJUNCTIVITIS
52
# **CHLAMYDIA TRACHOMATIS** DISEASE: **GENITAL TRACT INFECTIONS** Clinical presentation (MEN): ____
NGU, EPIDIDYMITIS
53
# **CHLAMYDIA TRACHOMATIS** DISEASE: **GENITAL TRACT INFECTIONS** Clinical presentation (WOMEN): ____
URETHRITIS CERVICITIS PID
54
# **CHLAMYDIA TRACHOMATIS** DISEASE: **GENITAL TRACT INFECTIONS** TREATMENT: ____
Doxycycline Azithromycin (pregnant)
55
# **CHLAMYDIA TRACHOMATIS** DISEASE: **CHALMYDIAL PNEUMONIA** Clinical presentation: ____
NEONATAL PNEUMONIA
56
# **CHLAMYDIA TRACHOMATIS** DISEASE: **CHALMYDIAL PNEUMONIA** TREATMENT: ____
AZITHROMYCIN
57
# **CHLAMYDIA TRACHOMATIS** DISEASE: **LYMPHOGRANULOMA VENERUM** TREATMENT: ____
Doxycycline & erythromycin
58
# **CHLAMYDIA TRACHOMATIS** DISEASE: **LYMPHOGRANULOMA VENERUM** Clnical rpesentation: ____
lesions on genitalia & lymph nodes
59
# **CHLAMYDIA TRACHOMATIS** DISEASE: **TRACHOMA** TREATMENT: ____
AZITHROMYCIN
60
# **CHLAMYDIA PNEUMONIAE** **most infections** are ____ or ____
mild or asymptomatic
61
# **CHLAMYDIA PNEUMONIAE** **primary** illness
ATYPICAL PNEUMONIA
62
* Most infections are **mild** or **asymptomatic** * Primary illness: **Atypical pneumonia** * Causes **upper** and **lower respiratory tract infections ** o **Pharyngitis** o **Sinusitis** and **otitis media** may occur accompanied by lower airway disease.
CHLAMYDIA PNEUMONIAE
63
# **CHLAMYDIA PSITTACI** DISEASE
PSITTACOSIS
64
# **CHLAMYDIA PSITTACI** transmission
inhalation of **feces** from **infected birds**
65
66
# **CHLAMYDIA PSITTACI** causes
atypical pneumonia
67
# **CHLAMYDIA PSITTACI** DRUG OF CHOICE
Doxycycline
68
* There is a **patchy** inflammation of the lungs * The **liver**, **spleen**, **heart**, and **kidney** are often **enlarged** and **congested**
CHLAMYDIA PSITTACI
69
* Causative bacterium **cannot be isolated** on **routine media ** * **Does not resemble pneumococcal pneumonia**. * Causes: o **Mycoplasma** pneumoniae o **Legionella** pneumophila o **Chlamydia** **pneumoniae** o **Chlamydia psittaci** o **Coxiella burnetii** o Viruses such as such as **influenza virus** and **adenovirus**
ATYPICAL PNEUMONIA

MICROPARA (37 decks)

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