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MICROPARA > M5 PART 11 > Flashcards

M5 PART 11 Flashcards

1
Q
  • Obligate intracellular parasites
  • Vector borne
  • Pleomorphic coccobacilli
A

RICKETTSIA

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2
Q

RICKETTSIA

VISIBLE UNDER WHAT STAINS

A

Giemsa stain
Gimenez stain
Acridine orange

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3
Q

RICKETTSIA

grow readily in ____

A

yolk sacs of embryonated eggs

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4
Q

RICKETTSIA | ANTIGENIC STRUCTURES

contain ____ and cell wall surface protein ____ and ____

A

LPS
OmpA
Ompb

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5
Q

RICKETTSIA | ANTIGENIC STRUCTURES

These surface proteins are important in adherence to host cells and in the humoral immune response and also provide the basis of serotyping

A

OmpA
OmpB

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6
Q

RICKETTSIA

  • measures the presence of antirickettsial antibodies
  • Serum antibody will be agglutinated
A

WIEL FELIX TEST

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7
Q

RICKETTSIA | PATHOLOGY

Multiply in ____ of small blood vessels and produce vasculitis characterized by lymphocytes that surround the blood vessels

A

ENDOTHELIAL CELLS

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8
Q

RICKETTSIA | PATHOLOGY

Vasculitis lesions are prominent in the ____

A

skin

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9
Q

characterized by fever, headache, malaise, prostration, skin rash, and enlargement of the spleen and liver.

A

RICKETTSIA

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10
Q

RICKETTSIA PROWAZEKII

VECTOR

A

BODY LOUSE

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11
Q

RICKETTSIA PROWAZEKII

RESERVOIR

A

HUMANS

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12
Q

RICKETTSIA PROWAZEKII | DISEASES

  • systemic infection and prostration are severe and fever lasts for about 2 weeks.
  • The disease is more severe and more fatal in patients older than 40 years of age.
  • During epidemics, the case fatality rate has been 6 – 30%
A

Epidemic typhus (louse born typhus)

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13
Q

RICKETTSIA PROWAZEKII | DISEASES

  • recurrence of an old typhus
  • can reccur as long as 50 years later
  • Milder
  • Reactivated form of epidemic typhus (organism entered a stage of latency → reactivate)
A

Brill-Zinsser disease

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14
Q

common clinical manifestation in RICKETTSIA

A

RASHES

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15
Q

RICKETTSIA TYPHII

vector

A

FLEA

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16
Q

RICKETTSIA TYPHII

RESERVOIR

A

RODENTS

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17
Q

milder than epidemic typhus
fatal for elderly

A

RICKETTSIA TYPHII

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18
Q

RICKETTSIA TYPHII | DISEASES

Has many clinical features in common with that of epidemic typhus, but the disease is milder and is rarely fatal except in elderly patients

A

endemic typhus (flea-borne typhus) or
murine typhus

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19
Q
  • fever, chills, myalgia, headache, rash (no eschar);
  • milder illness than epidemic typhus
A

RICKETTSIA TYPHII

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20
Q

RICKETTSIA RICKETSII

vector

A

ticks

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21
Q

RICKETTSIA RICKETSII

reservoir

A

rodents
dogs

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22
Q

RICKETTSIA RICKETSII

disease

A

rocky mountain spotted fever

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23
Q

RICKETTSIA RICKETSII | DISEASE

Inward appearance of pustules
extremitis → inward to trunk → palm & soles

A

Rocky Mountain spotted fever (RMSF)

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24
Q
  • fever, HA, rash (no eschar); many systemic manifestation (hemorrhage, pulmonary edema)
  • Higher mortality rate
  • occur 3-5 days after the illness
  • life threatening for all age groups
A

RICKETTSIA RICKETSII

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25
Q

RICKETTSIA AKARI

vector

A

mites

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26
Q

RICKETTSIA AKARI

reservoir

A

mice

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27
Q

RICKETTSIA AKARI

disease

A

rickettsial pox

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28
Q

RICKETTSIA AKARI

  • Mild disease with a vesicular rash resembling that of varicella
  • Resembles chicken pox
  • About 1 week before onset of fever, a firm red papule appears at the site of the mite and develops into a deep-seated vesicle that in turn forms a black eschar
A

RICKETTSIAL POX

29
Q

mild illness, fever, headache, vesicular rash (eschar)

A

RICKETTSIA AKARI
Rickettsial pox

30
Q

ORIENTIA TSUTSUGAMUSHI

vector

A

mites

31
Q

ORIENTIA TSUTSUGAMUSHI

reservoir

A

rodents

32
Q

ORIENTIA TSUTSUGAMUSHI

disease

A

scrub typhus

33
Q

ORIENTIA TSUTSUGAMUSHI

  • Fever, headache, rash, lymphadenopathy, atypical lymphocytes
  • One feature is the eschar, the punched-out ulcer covered with a blackened scab that indicates the location of the mite bite
A

Scrub typhus

34
Q

fever, headache, rash (50% have eschar), lymphadenopathy, atypical lymphocytes

A

ORIENTIA TSUTSUGAMUSHI
Scrub typhus

35
Q

ORIENTIA TSUTSUGAMUSHI

DRUG OF CHOICE

A

doxycycline

36
Q

ORIENTIA TSUTSUGAMUSHI

can enhance the disease and are contraindicated

A

SULFONAMIDES

37
Q

COXIELLA BURNETII

STAIN

A

Gimenez

38
Q

COXIELLA BURNETII

resistant to

A

drying
may survive pasteurization

39
Q

COXIELLA BURNETII

TRANSMISSION

A

inhalation of aerosol

40
Q
  • Small obligate organisms that have a membrane similar to gram negative bacteria
  • grows in cytoplasmic vacuoles
  • Stains with Gimenez
  • Resistant to drying and may survive pasteurization at 60 deg C for 30 minutes
  • Transmission is via inhalation of aerosol
  • Vector transmission: only possible in aqnimals
A

COXIELLA BURNETII

41
Q

COXIELLA BURNETII | PHASES

  • virulent form found in humans with Q fever and in infected vertebrate animals
  • LPS is expressed
A

PHASE I

42
Q

COXIELLA BURNETII | PHASES

  • not infectious and occur only by seria passage in cell cultures
  • the MO lost its ability to synthesize the antigen used for infections
A

PHASE II

43
Q

COXIELLA BURNETII

disease

A

Q FEVER

44
Q

COXIELLA BURNETII | DISEASE

  • resembles influenza
  • nonbacterial pneumonia and hepatitis
  • recovery is possible
A

ACUTE DISEASE

45
Q

COXIELLA BURNETII | DISEASE

  • infective endocarditis is the most common form of disease in this phase
  • lasts for more than 6 months
  • rarely occurs
A

CHRONIC DISEASE

46
Q

COXIELLA BURNETII

DRUG OF CHOICE

A

doxycycline

47
Q
  • Obligate intracellular bacteria
  • Their cell wall is rigid, but do not have a typical peptidoglycan layer because it lacks muramic acid.
  • MOMP is an important structural component peptidoglycan – N-acetyl, glucosamine, N-acetyl muramic acid, major outer membrane protein
A

CHLAMYDIA

48
Q

CHLAMYDIA

Lacks ____ in peptidoglycan

A

MURAMIC ACID

49
Q

CHLAMYDIA

used for adhesion

A

MOMP

50
Q

CHLAMYDIA

All chlamydia possesses ____

A

shared group specific antigen

51
Q

CHLAMYDIA TRACHOMATIS

DISEASE: TRACHOMA
Clinical presentation: ____

A

CHRONIC KERATOCONJUNCTIVITIS

52
Q

CHLAMYDIA TRACHOMATIS

DISEASE: GENITAL TRACT INFECTIONS
Clinical presentation (MEN): ____

A

NGU, EPIDIDYMITIS

53
Q

CHLAMYDIA TRACHOMATIS

DISEASE: GENITAL TRACT INFECTIONS
Clinical presentation (WOMEN): ____

A

URETHRITIS
CERVICITIS
PID

54
Q

CHLAMYDIA TRACHOMATIS

DISEASE: GENITAL TRACT INFECTIONS
TREATMENT: ____

A

Doxycycline
Azithromycin (pregnant)

55
Q

CHLAMYDIA TRACHOMATIS

DISEASE: CHALMYDIAL PNEUMONIA
Clinical presentation: ____

A

NEONATAL PNEUMONIA

56
Q

CHLAMYDIA TRACHOMATIS

DISEASE: CHALMYDIAL PNEUMONIA
TREATMENT: ____

A

AZITHROMYCIN

57
Q

CHLAMYDIA TRACHOMATIS

DISEASE: LYMPHOGRANULOMA VENERUM
TREATMENT: ____

A

Doxycycline & erythromycin

58
Q

CHLAMYDIA TRACHOMATIS

DISEASE: LYMPHOGRANULOMA VENERUM
Clnical rpesentation: ____

A

lesions on genitalia & lymph nodes

59
Q

CHLAMYDIA TRACHOMATIS

DISEASE: TRACHOMA
TREATMENT: ____

A

AZITHROMYCIN

60
Q

CHLAMYDIA PNEUMONIAE

most infections are ____ or ____

A

mild or asymptomatic

61
Q

CHLAMYDIA PNEUMONIAE

primary illness

A

ATYPICAL PNEUMONIA

62
Q
  • Most infections are mild or asymptomatic
  • Primary illness: Atypical pneumonia
  • Causes upper and **lower respiratory tract infections **
    o Pharyngitis
    o Sinusitis and otitis media may occur accompanied by lower airway disease.
A

CHLAMYDIA PNEUMONIAE

63
Q

CHLAMYDIA PSITTACI

DISEASE

A

PSITTACOSIS

64
Q

CHLAMYDIA PSITTACI

transmission

A

inhalation of feces from infected birds

65
Q
A
66
Q

CHLAMYDIA PSITTACI

causes

A

atypical pneumonia

67
Q

CHLAMYDIA PSITTACI

DRUG OF CHOICE

A

Doxycycline

68
Q
  • There is a patchy inflammation of the lungs
  • The liver, spleen, heart, and kidney are often enlarged and congested
A

CHLAMYDIA PSITTACI

69
Q
  • Causative bacterium cannot be isolated on **routine media **
  • Does not resemble pneumococcal pneumonia.
  • Causes:
    o Mycoplasma pneumoniae
    o Legionella pneumophila
    o Chlamydia pneumoniae
    o Chlamydia psittaci
    o Coxiella burnetii
    o Viruses such as such as influenza virus and adenovirus
A

ATYPICAL PNEUMONIA

MICROPARA (37 decks)

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