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MICROPARA > M5 PART 6 > Flashcards

M5 PART 6 Flashcards

1
Q
  • aerobic (5% – 10%), Gram-negative
  • non-motile diplococcus
  • Kidney bean shaped
  • Culture: Sheep blood agar, chocolate agar
A

NEISSERIAE

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2
Q

NEISSERIAE

oxygen requirement

A

aerobic

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3
Q

NEISSERIAE

motility

A

nonmotile

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4
Q

NEISSERIAE

shape

A

kidney bean shaped

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5
Q

NEISSERIAE

culture media

A

sheep blood agar, chocolate agar

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6
Q

Neisseria gonorrhoeae

POE

A

genital tract

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7
Q

Neisseria gonorrhoeae

maltose formation

A

negative

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8
Q

Neisseria gonorrhoeae

β-lactamase production

A

some

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9
Q

Neisseria gonorrhoeae

vaccine

A

no

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10
Q

Neisseria meningitidis

POE

A

respiratory tract

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11
Q

Neisseria meningitidis

maltose formation

A

positive

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12
Q

Neisseria meningitidis

β-lactamase production

A

none

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13
Q

Neisseria meningitidis

vaccine

A

yes

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14
Q

NEISSERIAE GONORRHOEAE | ANTIGENIC STRUCTURE

  • they enhance adhesion to host cells & resistance to phagocytosis
  • important to establish a disease
A

PILI (FIMBRIAE)

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15
Q

NEISSERIAE GONORRHOEAE | ANTIGENIC STRUCTURE

  • it forms pores in the surface
  • Prevent fusion of phagosome with lysosome
A

POR PROTEIN

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16
Q

NEISSERIAE GONORRHOEAE | ANTIGENIC STRUCTURE

adhesion and migration of the bacteria

A

OPA (OPACITY) PROTEIN

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17
Q

NEISSERIAE GONORRHOEAE | ANTIGENIC STRUCTURE

  • reduction modifiable protein
  • It associates with Por protein
A

Rmp (protein III)

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18
Q

NEISSERIAE GONORRHOEAE | ANTIGENIC STRUCTURE

  • has endotoxin
  • fewer sugar
A

LIPOOLIGOSACCHARIDES (LOS)

19
Q

NEISSERIAE GONORRHOEAE | PATHOGENESIS & CLINICAL FINDINGS

Gonococci attack ____ of the GUT, eye, rectum, and throat

A

mucus membrane

20
Q

NEISSERIAE GONORRHOEAE | PATHOGENESIS & CLINICAL FINDINGS

Gonococci attack mucus membrane of the GUT, eye, rectum, and throat

A

chronic inflammation
fibrosis

21
Q

NEISSERIAE GONORRHOEAE | PATHOGENESIS & CLINICAL FINDINGS

GONORRHEA:
urethritis, with yellow, creamy pus, and painful urination

22
Q

NEISSERIAE GONORRHOEAE | PATHOGENESIS & CLINICAL FINDINGS

GONORRHEA:
primary infection is in the endocervix and extends to the urethra and vagina, giving rise to mucopurulent discharge; half of the women are asymptomatic carriers

23
Q

NEISSERIAE GONORRHOEAE | PATHOGENESIS & CLINICAL FINDINGS

local gonorrheal infection in women

24
Q

NEISSERIAE GONORRHOEAE | PATHOGENESIS & CLINICAL FINDINGS

ascending gonorrheal infection in women

A

PELVIC INFLAMMATORY DISEASE (PID)

25
Q

NEISSERIAE GONORRHOEAE | PATHOGENESIS & CLINICAL FINDINGS

  • salpingitis (frequent complication in women when the infection ascends to the uterine tube)
  • May lead to ectopic pregnancy
  • Infertility may occur in 20% of the women with gonococcal salpingitis
A

PELVIC INFLAMMATORY DISEASE (PID)

26
Q

NEISSERIAE GONORRHOEAE | PATHOGENESIS & CLINICAL FINDINGS

  • Skin lesions (especially hemorrhagic papules and pustules) on the hands, forearms, feet, and legs
  • Tenosynovitis and suppurative arthritis, usually of the knees, ankles, and wrists
A

Gonococcal bacteremia

27
Q

NEISSERIAE GONORRHOEAE | PATHOGENESIS & CLINICAL FINDINGS

  • Gonococcal ophthalmia neonatorum, an infection of the eye in newborns
  • can be passed to newborns via vaginal delivery
A

NEONATAL INFECTIONS

28
Q

NEISSERIAE GONORRHOEAE | PATHOGENESIS & CLINICAL FINDINGS

infection of the eye in newborns

A

Gonococcal ophthalmia neonatorum

29
Q

NEISSERIAE GONORRHOEAE | TREATMENT

DOC:
uncomplicated genital or rectal infections

A

ceftriaxone IM
azithromycin

30
Q

NEISSERIAE GONORRHOEAE | TREATMENT

Patient with azithromycin allergy

A

DOXYCYCLINE

31
Q

NEISSERIAE GONORRHOEAE | PATHOGENESIS & CLINICAL FINDINGS

prevention of neonatal infections

A

instillation of erythromycin ointment

32
Q

NEISSERIAE MENINGITIDIS | ANTIGENIC STRUCTURES

serogroup A, B, QC, X, Y

A

capsular polysaccharide

33
Q

NEISSERIAE MENINGITIDIS | ANTIGENIC STRUCTURES

for humans

34
Q

NEISSERIAE MENINGITIDIS | ANTIGENIC STRUCTURES

outer membrane

A

proteins & LPS

35
Q

NEISSERIAE MENINGITIDIS | PATHOGENESIS

POE

A

respiratory tract

36
Q

NEISSERIAE MENINGITIDIS | ANTIGENIC STRUCTURES

what makes it unique

A

N-acetyl-mannosamine

37
Q

NEISSERIAE MENINGITIDIS | PATHOGENESIS

Nasopharynx → bloodstream

A

meningococcal bacteremia

38
Q

NEISSERIAE MENINGITIDIS | PATHOGENESIS

“Flu-like” infection

A

invasive meningococcal disease (MID)

39
Q

NEISSERIAE MENINGITIDIS | CLINICAL FINDIGNS

intense headache, vomiting, photophobia, confusion, and stiff neck → COMA; common complication of meningococcal bacteria in age 2 to 18 years old

A

MENINGITIS

40
Q

NEISSERIAE MENINGITIDIS | CLINICAL FINDIGNS

  • High fever and rash
  • Waterhouse-Friderichsen syndrome
  • Disseminated intravascular coagulation (DIC) → circulatory collapse and adrenal insufficiency
A

MENINGOCOCCEMIA (sepsis)

41
Q

NEISSERIAE MENINGITIDIS | CLINICAL FINDIGNS

most severe

A

Waterhouse-Friderichsen syndrome

42
Q

NEISSERIAE MENINGITIDIS | TREATMENT

DOC

A

PENICILLIN G

43
Q

NEISSERIAE MENINGITIDIS | TREATMENT

ALTERNATIVES

A

chloramphenicol
cefotaxime
ceftriaxone

MICROPARA (37 decks)

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