More Liver and Gastro Flashcards
Liver, Dumping Syndrome, and IBD
What are the results of iron studies in pts w/ hemochromatosis: Fe, ferritin, TIBC?
Fe up
ferritin up
TIBC down
How do you treat hemochromatosis pts who overabsorb iron?
phlebotomy
How do you treat pts w/ hemochromatosis who have been over-transfused?
deferoxamine
Cirrhosis + choreiform movement + psyhcosis
Wilson disease
What is the tx for Wilson’s disease?
penicillamine
What are the 3 tx options for chronic HBV?
interferon OR lamivudine OR adefovir
What is the tx of chronic HCV?
interferon + ribavirin
What is the first test to used to confirm suspected Wilson’s disease?
serum ceruloplasmin
What other common complication of longstanding diabetes has a similar pathophysiology to diabetic gastroparesis?
peripheral neuropathy
What is the primary stimulant of gastrin release?
distention
What 2 drugs are used for the Tx of diabetic gastroparesis?
Erythromycin and Metoclopramide
What class of Abx does erythromycin belong to?
macrolides
What ECG abnormality can macrolides cause?
Prolonged QT interval
Metoclopramide is both a prokinetic and a(n) _______.
anti-emetic
What 2 things cause dizziness, sweating in dumping syndrome?
hypoglycemia and intravascular volume depletion
Whish type of IBD is ANCA+?
UC
Which type of IBD is ASCA+?
Crohns
Name 3 adverse effects of sulfasalazine (for the 10-30% of the population w/ sulfa sensitivity).
rash, hemolysis, and renal problems
What specific renal problem does sulfasalazine cause?
Allergic Interstitial Nephritis
What steroid is used for acute exacerbations of IBD?
Budesonide
Why is budesonide the steroid of choice for IBD exacerbations?
highly susceptible to first-pass effect –> no systemic efftects!
The first line drugs for chronic IBD are all derivatives of what?
mesalamine
The 3 main mesalamine-based drugs for IBD all have what 3 letters in their names?
ASA - Pentasa (or 5-ASA), AsaCol, and Rowasa
What 2 other immunomodulant drugs (not mesalamine) are used chronically for IBD?
6-MP, azothioprine
What Abx are used to prevent perirectal/perianal disease in Crohns?
Vanco, metro
