Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

HUBS 192 > Lecture 32: Glomerular function > Flashcards

Lecture 32: Glomerular function Flashcards

1
Q

Filtration is a specific form of what?

A

Ultrafiltration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is ultrafiltration?

A

Filtration on a micro scale

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Filtration creates what?

A

A plasma-like filtrate of the blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Filtration at the glomeruli is what?

A

Not particularly selective

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is filtration at the glomeruli influenced slightly by?

A

Charge and size of molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the average rate of filtration?

A

125mL/min or 180L/day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Filtration produces how much urine?

A

1.5L per day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

The glomerulus has afferent and efferent arterioles supplying it with what?

A

Blood for filtration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What % of cardiac output does the renal blood supply receive?

A

20-25%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

At what rate does the renal blood supply receive blood?

A

1-1.2L/min

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the high flow of renal blood supply for?

A

Filtration rather than metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Where does filtration take place?

A

In the glomerulus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the filtration membrane of the glomerulus composed of?
(3)

A
  • Fenestrated endothelium
  • Basement membrane
  • Podocytes with foot processes and filtration slits
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Small substances with low molecular mass are what?

A

Freely filtered

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Large substances with high molecular mass are what?

A

Not filtered

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is glomerular filtration determined by?

3

A
  • Forces/pressure gradients between glomerular capillary/capsular space
  • Permeability of glomerular capillary
  • Surface area of glomerular capillary
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are the 4 forces determining net filtration pressure?

A
  • Glomerular hydrostatic pressure (GHP)
  • Blood colloid osmotic pressure (BCOP)
  • Capsular hydrostatic pressure(CsHP)
  • Capsular colloid osmotic pressure (CsCOP)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What does the Glomerular hydrostatic pressure (GHP) =?

A

Blood pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What does the Blood colloid osmotic pressure (BCOP) =?

A

Albumin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What does the Capsular hydrostatic pressure(CsHP) =?

A

Corpuscle embedded in tissue

21
Q

What does the Capsular colloid osmotic pressure (CsCOP) =?

A

No protein in the capsular space

22
Q

What force cause filtration into the glomerular space from the capillary?

A

Glomerular hydrostatic pressure (GHP)

23
Q

What forces cause filtration into the capillary from the capsular space?

A
  • Blood colloid osmotic pressure (BCOP)

- Capsular hydrostatic pressure(CsHP)

24
Q

What is the equation for the clearance of a substance?

A

Clearance (C) = U x V / P (in mL/min)

25
Q

What does U =?

A

Concentration of S in urine (mg/L or mol/L)

26
Q

What does V=?

A

Volume of urine produced per unit time (mL/min or L/hour)

27
Q

What does P=?

A

Concentration of S in plasma (mg/L or mol/L)

28
Q

What does the equation for renal clearance describe?

A

The rate at which substance is cleared by the kidney per unit time

29
Q

The equation for renal clearance describes the clearance via the kidneys for what?

A

All substances that can be detected in plasma and urine

30
Q

What does GFR stand for?

A

Glomerular filtration rate

31
Q

What is glomerular filtration rate?

A

Amount of fluid filtered per unit time

32
Q

What is the GFR normally?

A

Approximately 180 L/day or 125mL/minute

33
Q

GFR is/does what?

3

A
  • Tightly regulated
  • Varies from person to person
  • Declines slowly from age 30
34
Q

To be used as a measure of GFR a substance must what?

3

A
  • Not be reabsorbed
  • Not be secreted into the tubule
  • Not be metabolised
35
Q

What 2 substance fit the conditions to be used as a measurer of GFR?

A
  • Insuline

- Creatinine

36
Q

What is insulin?

2

A
  • A polysaccharide not metabolised by the body

- Not found in the body, must be injected

37
Q

What is creatine?

2

A
  • Waste product produced by muscles

- Already in the body so most commonly used clinically

38
Q

What happens to creatine at the glomerulus?

A

It is filtered freely but not reabsorbed/secreted/metabolised

39
Q

Plasma creatine is an indicator for what?

A

Kidney function

40
Q

What happens to plasma creatine levels if both kidneys are working?

A

It is low

41
Q

What happens to plasma creatine if only one kidney is working?

A

It is still fairly normal

42
Q

What happens if there is critical kidney function?

A

Kidneys are not working properly and it is important to consider for drug application

43
Q

How much renal blood is filtered?

A

Only about 20%

half of the CO is plasma therefore it is only 20% of the 1/2 of CO that is filtered

44
Q

What is the filtration fraction?

A

GFR/RPF

45
Q

What does RPF mean?

A

Renal plama flow

46
Q

What is filtered load?

A

The amount of a particular substance (solute) filtered per minute

47
Q

What does filtered load =?

A

GFR x solute plasma conc.

48
Q

What is a typical value for GFR?

A

125mL/min

HUBS 192 (38 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions