FN: Thyroid drugs

Question 1

Thyroid drugs

Answer 1

Thyroxine
Carbimazole
Propythiouracil
Radioiodine

Question 2

Thyroxine SE

Answer 2

Precipitation of heart failure
Osteopenia
AF
Over-Rx - hyperthyroidism

Question 3

Thyroxine Interactions

Answer 3

W+

Question 4

Thyroxine note

Answer 4

Introduce slowly in elderly

Question 5

Carbimazole

Propythiouracil MOA

Answer 5

Thionamides

• Thyroperoxidase inhibitos
• Prevent iodination of tyrosine –> reduced T4/T3 synthesis

Carbimazole is a pro-drug - converted to methimazole

Question 6

Carbimazole

Propythiouracil SE

Answer 6

Agranulocytes
-often transient and benign

Hypersensitivity: rash, pruritis

Hepatitis

Question 7

Carbimazole

Propythiouracil Contrainidications

Answer 7

Pregnancy
Children
Tracheal compression - do surgery

Question 8

Carbimazole

Propythiouracil other

Answer 8

Propythiouracil is reserved for those intolent of carbimazole due to risk of hepatitis

Titrate to normal TSH or block and replace

Question 9

Radioiodine: MOA

Answer 9

Radioiodine is localised to thyroid - destructino of gland

Question 10

Radioiodine SE

Answer 10

Hypothyroidism

Can precipitate thyroid storm

Question 11

Radioiodine Other

Answer 11

Stop thionamide before use