FN: Non-alcoholic Fatty Liver Disease (NAFLD) Flashcards
1
Q
Description
A
Cryptogenic cause of hepatitis and cirrhosis assoc. ̄c insulin resistance and the metabolic syndrome.
Non-alcoholic steatohepatitis (NASH) is most extreme form and → cirrhosis in 10%
2
Q
RF
A
Obesity
HTN
T2DM
Hyperlipidaemia
3
Q
Presentation
A
Mostly asymptomatic
Hepatomegaly and RUQ discomfort may be present.
4
Q
Metabolic Syndrome
A
Central obesity (↑ waist circumference) and two of: ↑ Triglycerides
↓ HDL
HTN
Hyperglycaemia: DM, IGT, IFG
5
Q
Ix
A
BMI
Glucose, fasting lipids
↑ transaminases: AST:ALT <1 Liver biopsy
6
Q
Mx
A
Lose wt.
Control HTN, DM and lipids
