FN: SLE

Question 1

Definition

Answer 1

Multisystemic autoimmune inflammatory disease in which autoAbs to a variety of autoantigens result in the formation and deposition of immune complexes

Question 2

Epi

Answer 2

Prev: 0.2%
Sex: F»M = 9:1
Age: Child-bearing age
Genetic: increased in Afro-Caribs and ASians

Question 3

Features

Answer 3

Relapsing, remitting history

Constitutional symptoms: fatigue, wt loss, fever, myalgia

Question 4

Way to remember features

Answer 4

A RASH POINst an MD

Question 5

Features of SLE

Answer 5

Arthritis
ANA
Serositis
Haematological
Photosensitivity
Oral ulcers
Immune phenomenon
Neurological
Malar Rash
Discoid Rash

Question 6

Arthritis in SLE

Answer 6

Non erosive, involving peripheral joints

Jaccouds: reducible deforming arthopathy

Question 7

Renal

Answer 7

Proteinuria and increased BP

Question 8

ANA

Answer 8

positive in 95%

Question 9

Serositis

Answer 9

Pleuritis: pleuritic pain, dyspnoea, effusion
Pericarditis: chest pain relieved by sitting forwards

Question 10

Haematological

Answer 10

AIHA
reduced WCC
Reduced platelets

Question 11

Immune phenonmenon

Answer 11

Anti-dsDNA
Anti-Sm
Anti-phospholipid

Question 12

Neurological

Answer 12

Seizures, pyschosis

Question 13

Malar rash

Answer 13

Facial erythema spring the nasolabial folds

Question 14

Discoid Rash

Answer 14

Erythema - pigmented hyperkeratotic papules - atrophic depressed lesions
Mainly affects face and chest

Question 15

Monitoring disease activity

Answer 15

Anti-dsDNA titres
Complement: reduced C3 and Cd
increased ESR

Question 16

OTher investigations

Answer 16

Bloods: FBC, U and E, CRP clotting (usually normal)
Urine:stix, PCR

Question 17

Drug induced Lupus

Cause

Answer 17

Procainamide,
phenytoin,
hydralazine,
isoniazid

Question 18

Ab results

Answer 18

Anti-histone Abs in 100%

Question 19

Signs

Answer 19

Mostly skin and lungs

Question 20

Cure

Answer 20

Disease remits if drug stopped