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[2ND YEAR] CCP 5 - Pharmaceutical Microbiology & Parasitology (Lec) > FINAL 02 - Viral Hepatitis and Gastroenteritis > Flashcards

FINAL 02 - Viral Hepatitis and Gastroenteritis Flashcards

1
Q

A systemic disease primarily involving the liver; produces acute inflammation of the liver

A

Viral hepatitis

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2
Q

Hepatitis wherein more extensive damage may occur that prevents orderly liver cell regeneration

A

Fulminant hepatitis

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3
Q

Chronic carriers of __________ may or may not have demonstrable evidence of liver disease

A

HBsAg

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4
Q

Hepatitis that is a mild benign disease; characterized by abnormal aminotransferase values and hepatomegaly

A

Persistent (Unresolved) viral hepatitis

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5
Q

Hepatitis characterized by inflammation and necrosis to collapse of the normal reticulum framework

A

Chronic active hepatitis

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6
Q

A member of the Picornaviridae family; causes hepatitis A; transmitted through the fecal-oral route (Types of hepatitis virus)

A

Hepatitis A virus (Enterovirus-72)

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7
Q

Hepatitis A virus is a member of the __________ family

A

Picornaviridae family

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8
Q

Hepatitis A virus causes __________

A

Hepatitis A (Infectious hepatitis)

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9
Q

Refers to the Hepatitis A virus (Hepatitis A laboratory findings)

A

HAV

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10
Q

Refers to the antibody to HAV (Hepatitis A laboratory findings)

A

Anti-HAV

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11
Q

Refers to the IgM class antibody to HAV; indicates recent infection with hepatitis A (Hepatitis A laboratory findings)

A

IgM anti-HAV

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12
Q

Prevention for Hepatitis A virus

A

Inactivated vaccine

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13
Q

A member of the Hepadnaviridae family; causes hepatitis B (Serum hepatitis); has reverse transcriptase; transmitted parenterally (Types of hepatitis virus)

A

Hepatitis B virus

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14
Q

Hepatitis B virus is a member of the __________ family

A

Hepadnaviridae family

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15
Q

Hepatitis B virus causes __________

A

Hepatitis B (Serum hepatitis)

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16
Q

Hepatitis B virus has __________, which means it replicated through intermediate RNA, resembling a retrovirus

A

Reverse transcriptase

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17
Q

Virion of Hepatitis B virus

A

Dane particle

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18
Q

Refers to the irreversible fibrosis (scarring) of the liver

A

Liver cirrhosis

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19
Q

People with Hepatitis B are at a higher risk of developing __________

A

Hepatocellular carcinoma

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20
Q

Refers to the hepatitis B virus (Hepatitis B laboratory findings)

A

HBV

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21
Q

Refers to the hepatitis B surface antigen (Hepatitis B laboratory findings)

A

HBsAg

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22
Q

Refers to the hepatitis B e antigen (Hepatitis B laboratory findings)

A

HBeAg

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23
Q

Refers to the hepatitis B core antigen (Hepatitis B laboratory findings)

A

HBcAg

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24
Q

Refers to the antibody to HBsAg; indicates past infection and immunity to HBV (Hepatitis B laboratory findings)

A

Anti-HBs

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25
Q

Refers to the antibody to HBsAg (Hepatitis B laboratory findings)

A

Anti-HBs

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26
Q

Refers to the antibody to HBeAg (Hepatitis B laboratory findings)

A

Anti-HBe

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27
Q

Refers to the antibody to HBcAg; indicates infection with HB at some undefined time in the past (Hepatitis B laboratory findings)

28
Q

Refers to the IgM class antibody to HBcAg; indicates recent infection with HBV (Hepatitis B laboratory findings)

A

IgM anti-HBc

29
Q

A general marker of infection; presence indicates current infection; absence may indicate lack of infection, past infection, or immunization

30
Q

3 treatments given for chronic Hepatitis B infection (PET)

A

Pegylated interferon alfa-2a, Entecavir, Tenofovir

31
Q

Hepatitis B vaccine given to all newborns

A

Hepatitis B subunit vaccine (HBsAg)

32
Q

Hepatitis B vaccine given to newborns of infected mothers or within 14 days after sexual exposure

A

Hepatitis B immunoglobulin (HBIG)

33
Q

Hepatitis C virus is a member of the __________ family, but it is not vector-borne

A

Flaviviridae family

34
Q

Hepatitis C virus causes __________

A

Hepatitis C/Non-A hepatitis/Non-B hepatitis/Posttransfusion hepatitis

35
Q

Refers to the Hepatitis C virus (Hepatitis C laboratory findings)

36
Q

Refers to the antibody to HCV (Hepatitis C laboratory findings)

37
Q

Treatment for Hepatitis C (PR)

A

Pegylated interferon-alfa + Ribavirin

38
Q

A member of the Deltaviridae family; a defective virus dependent on coinfection with HBV; causes hepatitis D (Types of hepatitis virus)

A

Hepatitis D virus

39
Q

Hepatitis D virus is a member of the __________ family

A

Deltaviridae family

40
Q

An agent of the Hepatitis D virus that contains delta antigen (HDAg) surrounded by an HBsAg envelope

A

Delta agent

41
Q

Hepatitis D virus causes __________

A

Hepatitis D (Delta hepatitis)

42
Q

A severe acute infection; refers to fulminant hepatitis (Clinical findings of Hepatitis D virus)

A

Coinfection

43
Q

Refers to progression to cirrhosis (Clinical findings of Hepatitis D virus)

A

Superinfection

44
Q

Refers to the Hepatitis D virus (Hepatitis D laboratory findings)

45
Q

Refers to the delta antigen; detectable in early acute HDV infection (Hepatitis D laboratory findings)

46
Q

Refers to the antibody to delta-Ag; indicates past or present infection with HDV (Hepatitis D laboratory findings)

47
Q

A member of the Hepeviridae family; causes hepatitis E; responsible for a mortality rate in excess of 20% in pregnant women (Types of hepatitis virus)

A

Hepatitis E virus

48
Q

Hepatitis E virus is a member of the __________ family

A

Hepeviridae family

49
Q

Hepatitis E virus causes __________

A

Hepatitis E (Enterically transmitted hepatitis)

50
Q

Anti-HAV IgM positive is interpreted as _________ (Serologic markers of hepatitis)

A

Acute infection with HAV

51
Q

Anti-HAV IgG positive is interpreted as __________ (Serologic markers of hepatitis)

A

Past infection with HAV

52
Q

Anti-HCV positive is interpreted as __________ (Serologic markers of hepatitis)

A

Current or past infection with HCV

53
Q

Anti-HD positive, HBsAg positive is interpreted as __________ (Serologic markers of hepatitis)

A

Infection with HDV

54
Q

Anti-HD positive, anti-HBc IgM positive is interpreted as __________ (Serologic markers of hepatitis)

A

Coinfection with HDV and HBV

55
Q

Anti-HD positive, anti-HBc IgM negative is interpreted as __________ (Serologic markers of hepatitis)

A

Superinfection of chronic HBV infection with HDV

56
Q

A clinical syndrome which includes not only diarrhea, but also other symptoms like abdominal pain, nausea, and vomiting

A

Gastroenteritis

57
Q

About 90% of causes of acute viral gastroenteritis are caused by either the __________ or __________ (RN)

A

Rotavirus, Norovirus

58
Q

The most common cause of viral gastroenteritis; is wheel-shaped; is a member of Reoviridae family

59
Q

The rotavirus is ________ shaped

A

Wheel-shaped

60
Q

The rotavirus is a member of the __________ family

A

Reoviridae

61
Q

Oral live attenuated rhesus-based rotavirus vaccine; withdrawn due to incidence of intussusception (Rotavirus vaccine)

A

RotaShield

62
Q

Oral live attenuated pentavalent human-bovine reassortant rotavirus vaccine; 3 dose series from 6-32 weeks (Rotavirus vaccine)

63
Q

Oral live attenuated monovalent human rotavirus vaccine; 2 dose series from 6-24 weeks (Rotavirus vaccine)

64
Q

A member of Caliciviridae family; the most important cause of viral gastroenteritis (winter vomiting disease) in adults

A

Norovirus/Norwalk virus

65
Q

The norovirus is a member of the __________ family

A

Caliciviridae family

66
Q

Norovirus is the most important cause of __________ in adults

A

Epidemic viral gastroenteritis (Winter vomiting disease)

67
Q

A family of viruses that has a starlike morphology; causes sporadic cases of viral gastroenteritis

A

Astroviridae

[2ND YEAR] CCP 5 - Pharmaceutical Microbiology & Parasitology (Lec) (39 decks)

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