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Pharmacology > Drugs for CHD: Part 3 > Flashcards

Drugs for CHD: Part 3 Flashcards

1
Q

Drugs for thromboembolic conditions

A

Platelet inhibitors
Anticoagulants
Thrombolytic agents

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2
Q

Platelet inhibitors

A

Inhibit platelet aggregation

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3
Q

Examples of platelet inhibitors

A

Aspirin and plavix

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4
Q

Platelet inhibitors prevent…

A

MI or CVA in patients with family history
Repeat MI or CVA
CVA for patients having TIA

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5
Q

Aspirin

A

Inexpensive and effective

Family history but no past event

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6
Q

Plavix

A

Used in acute MI to prevent further damage or secondary MI

More potent

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7
Q

Heparin

A

Inactivates thrombin and inhibits conversion of fibrinogen to fibrin

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8
Q

Heparin is used..

A

To treat DVT / PE, MI, stroke

Prevention of DVT

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9
Q

Heparin can be given…

A

IV or subcutaneous

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10
Q

Heparin can be reversed with…

A

Protamine sulfate

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11
Q

Heparin does nor allow for…

A

Further clotting once it has occured

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12
Q

Duration of action of Heparin

A

Immediate onset but short duration of action

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13
Q

What should you monitor with heparin?

A

APTT

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14
Q

Lovenox (Enozaprin) - Low molecular weight heparin

A

Inactivates thrombin and prothrombin

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15
Q

What does Lovenox treat?

A

DVT prevention and treatment, MI, unstable angina, PE

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16
Q

Monitoring for Lovenox

A

None necessary because it is much more stable

17
Q

Coumadin

A

Inhibits Vitamin K dependent activation of clotting

18
Q

Coumadin is 99% bound to albumin so it…

A

Increases drug interactions

19
Q

Coumadin is used for…

A

Prophylaxis and treatment of blood clots

20
Q

Coumadin is given…

A

Orally (dosage varies by individual)

21
Q

Coumadin has a ____ half life

A

Very long

22
Q

Can you use coumadin in emergencies?

A

No because of its long onset of action

23
Q

Lab value for Coumadin

A

PT/IVR (important to monitor for risk of bleeding)

24
Q

“New” anti-coags

A

Non-valvular atrial fibrillation, treatment of DVT and PE

Much safer, same things as Coumadin

25
Q

Thrombolytics

A 
Altepase tPA (Activase) 
Converts plasminogen to plasmin, which destroys the fibrin in the clot
26
Q

Thrombolytics’ effects are within…

A

About 4 hours

27
Q

The risk for bleeding with thrombolytics is _______ than heparin and coumadin

A

Higher

28
Q

You never see thrombolytics used with….

A

Anticoagulants or other anti platelet drugs

Pharmacology (38 decks)

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