Drugs dor CHD: Part 1 Flashcards
Antihyperlipidemics
Decrease cholesterol
Coronary heart disease
Thickening of coronary arteries (deposition of fibrous plaque in the arterial wall)
CHD impeded coronary blood flow leading to…
Angina
Thrombi formation
MI
What do lipoproteins do?
Transport lipids (cholesterol & triglycerides) in blood
High density lipoproteins
“Good,” deliver cholesterol from tissues to liver
Low density lipoproteins
“Bad,” deliver cholesterol to tissues
Very low density lipoproteins
Deliver cholesterol to tissues
What is the #1 contributor to CHD?
LDLs
HDLs should be greater than ____ while LDLs should be lower than ____
60
100
Risk factors for CHD
Increased LDL Decreased HDL Smoking Diabetes Estrogen deficiency
Recommended lifestyle changes for CHD
Diet modification
Exercise (30-60 min)
Weight loss
Smoking cessation
Application of anti lipid drugs: approach
Reduce formation of atherosclerotic plaque which reduce narrowing of lumen in cardiac arteries
Antihyperlipidemics categories
HMG-CoA reductase inhibitors (statins) Bile acid sequestrants Nicotinic acid Fibric acid Ezetimibe
HMG-CoA Reductase Inhibitors (statins)
Rosuvastatin (Crestor) Atorvastatin (Lipitor) Simvastatin (Zocor) Fluvastatin (Lescol) Lovastatin (Mevacor)
What is the most predominant group used of the hyperlipidemic?
Statins
CoA reductase is responsible for…
Cholesterol synthesis in the liver
Statins mechanism of action
Inhibit HMG-CoA reductase
Decreases LDL, VLDL, & triglycerides
Slightly increases HDL
Statins promote ____ and reduces _____
Plaque stability
Risk of thrombosis
Can statins be combined with antihypertensives?
Yes
Statins are a ______ commitment
Lifetime
What are the most effective drugs that we have with the fewest adverse effects?
Statins
Adverse effects of statins
Hepatotoxicity GI side effects Headaches Myalgias Rhabdomyolysis
Myalgias
Muscle weakness
Rhabdomyolysis
Muscle weakness where sequelae causes muscles to be broken down, myoglobin deposited in the kidneys
