Chapter 24: GI Tract Infections Flashcards
John Snow demonstrated that Cholera is transmitted from
Contaminated water
GI tract refers to
Stomach and intestines
Hollow tube from mouth to anus is called
Digestive tract
Salivary glands, liver, pancreas are collectively known as
Accessory Organs to the GI tract
Mouth, Salivary Glands, Esophagus, Stomach make up…
Upper digestive system
Dental caries are aka
Cavities
Gingivitis is when…
Gums become inflamed
Muscular tube from mouth to stomach
Esophagus
Mucus and saliva containing secretory Ig___ bathes the lining of the esophagus
A
Small and large intestines, pancreas, liver all make up the
Lower digestive system
What increases the surface area in the small intestines
Villi and microvilli
Streptococcus mutans cause which bacterial disease of the upper digestive tract
Dental caries (cavities)
Streptococcus mutant convert Sucrose and other sugars into Extracellular Insoluble Polysaccharides called
Glucans
_____ essential for development of dental caries on smooth tooth surfaces
Glucan
Periodontal disease includes these 2 illnesses
Gingivitis & Chronic periodontist
Chronic periodontist: destructive response that damages structures that support teeth: Destroys ______ that tie surface of tooth to bone
Periodontal Ligaments
Gums tender, bleed easily is called
Gingivitis
Bad breath, red shiny gums bleed easy, loosening of teeth (Periodontal ligaments errode) are hallmarks of this…
Chronic periodontist
The causative agent of Periodontal disease is mostly….
Gram-negative anaerobes
What percentage of 65 year Olds have periodontal disease
90%
Trench month / Meth month’s proper name is
Acute necrotizing ulcerative gingivitis (ANUG)
Which type of bacteria are most likely to be in the mouth
Anaerobes
This morphology of bacteria invade gum tissue and cause Acute Necrotizing Ulcerative Gingivitis
Spirochete
Stomach ulcers are caused by this bacteria
Helicobacter pylori gastritis
How is Helicobacter pylori transmitted
Fecal via oral route & well water
How do antibiotics + medication help with helicopylori
Inhibit acid production
This Viral disease of the upper digestive system called Oral Herpes Simplex consists of these (2)
Cold sores & fever blisters
Herpes simplex virus 1 affects this area
And HSV 2 affects this area
Generally, but both can affect either
- Oral
- Genital
Herpes simplex virus hides where in a latent form
Nerve cells
Herpes can be transmitted by fomites
T or F
T
Acyclovir targets HSV in this method & doesn’t affect latent virus
DNA polymerase
This Virus of the Upper digestive system is marked by
Swelling of Parotid Glands
Spasms of muscles in front of ear talking and chewing difficult
After puberty
Orchitis swelling of testicles 3 -4 times normal size
Mumps
Mumps a viral disease of the upper digestive tract can spread how long before and after symptoms
1 week before
2 weeks after
Gastroenteritis is better know as this
Stomach flu
In Dysentery associated with Gastroenteritis this is found in the stool
Blood and pus
In Gastroenteritis
_____ cause water and electorate loss
_____ cause cell death
Enterotoxins
Cytotoxins
Treatment for Gastroenteritis is
Oral rehydration therapy
Counter act the loss of fluid and electrolytes
This Bacterial disease of the lower digestive tract can amount to 20 liters of diarrea per day
Caused by Vibrio ____
Cholerae
This Bacterial disease has a high infectious dose_____
And a vibro shapped bacteria
Cholera
Vibro Cholera has this type of toxin
A/B
Fecal contaminated water most common causes of this Bacterial infection of the lower digestive tract
Foods including crab, oysters, vegetables implicated
Vibro Cholera
This Bacterial disease of the lower digestive tract has 4 causative agents
S. dysenteriae, S. flexneri, S. boydii, S. sonnei (Ordered from most to least virulent)
Shigellosis
specialized intestinal epithelial cells that are primarily found overlying GALT lymphoid follicles such as the Peyer’s patches in the ileum
M cells
These pathogens attach to specific receptors
Induce uptake by epithelial cells, multiply, cause actin polymerization to Propel cell to cell: Limiting exposure to immune system
Shigellosis
Some strains of Shigellosis produce Shiga toxin, this type of toxin_____ responsibile for Hemolytic Uremic Syndrome
HUS may cause Anemia and Kidney failure
A-B toxin
Gastroenteritis A Bacterial disease of the lower digestive system is caused by
Escherichia coli
Stains of E coli
____ strains from food contaminated with cow manure
STEC
E coli strains
____ causes diarrhea in infants and visitors to developing countries
ETEC
E coli stains
Primary cause of disease in young children in developing countries; not easily spread by direct control contact
EIEC
Salmonella enterica is the causative agent of this Bacterial disease of the lower digestive tract
Salmonella gastroenteritis
Children infected by pet reptiles is a common route of transmission of this bacteria
Salmonella enterica
Antimicrobial medications are not usually advised for this type of Lower Digestive tract disease
Salmonella
Examples of Enteric Fevers: systemic diseases that originate in the
Intenstines
Other _____ species –> Typhoid and Paratypoid fever
Salmonella
Salmonella Typhi & Paratyphi are Gram-negative members of this family of bacteria
Enterobacteriaceae
This lower bacterial digestive disease causes constipation, internal bleeding, which can lead to death.
Typhoid fever & paratyphoid fever
Campylobacteriosis
Fever diarrhea, vomiting
Dysentery in 1/2 cases
Is caused by this gram-negative rod
Campylobacter jejuni
Campylobacteriosis
Is most commonly spread by food born illnesses
Lives in the intestine tract of _____
Low infectious dose
Poultry
Campylobacter jejuni
Antibiotic associated diarrhea is known as
Clostridium difficle
More serious cases of this bacterial infection of the lower digestive tract can progress to Colitis
Producing pseudomembranes colitis
Clostridium difícil
This disease of the lower digestive tract forms endospores
Clostridium difficile
Most viral gastroenteritis worldwide in infants and children is caused by…
Rotavirus
Most common cause of viral gastroenteritis in the US
Class B bioterrorism agent
Norovirus gastroenteritis
Non-enveloped, single-stranded RNA viruses in Caliciviridae
Name this Viral infection of the lower digestive tract
Norovirus
Transmission of this virus by fecal-oral route, but also by aerosols and fomites
Highly contagious few than 20 virions
Common on cruise ships and dorms
MORE THAN 50% of food born illnesses from this Virus
Norovirus
This virus has double walled caspid
Double stranded RNA
Attenuated vaccine
While this one,
Single stranded RNA genome
Low infectious dose, epidemics common
No vaccine
Rotavirus
Norovirus
Atleast __ unrelated viruses can cause hepatitis, an inflammation of the liver
5
Most noticeable sign of hepatitis
Jaundice
Hepatitis A aka ______
Acute illness
Older children and adults show symptoms
Young children are asymptomatic
Infectious hepatitis
Hepatitis B aka ______
Ranges from asymptomatic to sever
Can become chronic 1 in 5 develop Cirrhosis which is ______
Serum hepatitis
Scarring of the liver
This is the most Mild hepatitis
C
No envelope single-stranded RNA virus of Picornavirde virus causes
Hepatitis A
This hepatitis is most likely from a server not washing their hands
Hepatitis A
Member of the Hepadnavirisae cause
Hepatitis B
Flavivirdae causes this
Hepatitis C
Which hepatitis doesn’t have a vaccine but uses Direct Acting Antivirals to interfer with specific Hepatitis encoded proteins
Hepatitis C
Which hepatitis is from fecal oral
Which is from blood / semen
A fecal
B / C blood / semen (semen is only a possibility in C)
This hepatitis is usually mild
Full recovery
No chronic carriers
A
This hepatitis can lead to Chronic disease (Cirrhosis & Cancer)
Can cross placenta
Vaccine available
B
Few or no symptoms
Can lead to Cirrhosis or Cancer
Chronic carriers
No vaccine
Type of hepatitis
Hepatitis C
This hepatitis
Blood semen
No vaccine
Prior HBV infection needed
Can Worsen hepatitis B
Cross the placenta
Hepatitis D
This hepatitis
Fecal oral
No vaccine
Similar to hepatitis A
Except server disease in pregnant women
Hepatitis E
This Protzoan disease of the lower digestive tract
Has 2 forms: Growing/ Feeding ____
Dormant ______
Giardia lamblia
Trophozoite / cyst
Hikers drinking from a stream are at risk for this…
Giardiasis
Does chlorination destroy Giardia cysts
No, they must be filtered out
The causative agent for this Protozan disease is Entamoeba histolytica
Ambiasis
Can Giardia lambila be transmitted from person to person
Yes
Entamoeba histolytica which causes the disease Amebiasis
Can penetrante intestine lining causing bloody diarrhea called
Amebic dysentery
Which is the feeding form of the Protozoans
Trophozites
Helicobacter survives acidic stomach acid by secreting _____, which breaks urea into carbon dioxide and Ammonia.
Ammonia _____ stomach acid
They use flagella to penetrante the mucous layer and attach to epithelium
Stomach acids damage exposed tissue, causing ___
Urease
Neutralizes
An ulcer
______ increase secretion of water and electrolytes.
_____ cause cell death
Enterotoxins
Cytotoxins
Hepatitis ___ has declined since 1995 (vaccine invented) but was the most common type until 2005.
Hepatitis ___ declined since mid 80s but is the most common type since 2005
Hepatitis __ is the least common type, but incidents have increased since 2012
A, B, C
Giardia ____ enter the mouth and pass through the acid stomach to the lower intestine where ____ are relased and multiply.
Dehydration in large intestine stimulates ____ development.
Which will mature and be eliminated from the feces
Cysts / trophozoites / cysts
paramyxovirus is the family in which this upper digestive tract virus comes from.
Mumps
paramyxoviruses causes these 3 viruses
1 of the upper digestive system
&
1 of the lower respitory system
&
1 of the skin
Mumps
RSV
Rubeola (measles)
Where does typhoid and paratyphoid come from.
Bacteria
Salmonella
What are cariogenic plaques
Decay on teeth
Pathogenesis of this disease is by calcium salts
Periodontal disease
3 types of enterobacteria rods
1 vibro
Salmonella
Shigella
Escherichia
Chlorea
Which enterobacter causes cell death
Shigella
Pathogenesis
Large number must be ingested
Attaches to epithelial of small intestine
Multiply on epithelial cells
Produce a/b exotoxin
Cholera
Is there a vaccine for cholera
Yes
Sever “Rice water” diarrhea is associated with
Cholera
Symptoms
Bloody diarrhea
Fever
Joint pain
Convulsiones
Shigellosis
Pathogenesis
Phagocytosis by macrophages
Released and enter Epithelial cells
Inside host phagosome Multiply & Kill host cells
Shigellosis
Small dose needed
Not killed by stomach acid
Fecal to oral transmission
No vaccine
Shigellosis
Ecoli
Adhere to and colonize on intestinal epithelium
ETEC Entrotoxicgenic
E coli (similar to Shigella)
Enters intestinal epithelial cells
Multiply inside, exit & infect other cells
EIEC Enteoinvasive
E coli
Diarrhea outbreaks in hospitals
Loss of microvilli
Epithelial surface thickens
Loss of ability to absorb nutrients
EPEC EnteroPathogenic
E coli
Sever Bloody diarrhea
Toxins cause death of intestinal epithelium
EHEC Enterohemorrhagic
This lower digestive Bacterial disease from animal sources is mild
From humans is fatal
Salmonella
Removal of the gall Bladder to stop carriers is this lower digestive tract bacteria
Salmonella typhii
How many trophocytes exit from each cyst
2
Pathogenesis
May cover intestine surface and prevent absorption
Bulky fatty feces
Gas due to bacterial breakdown
Giardia lamblia
Inflammation of gums and tissue around roots of teeth is called Periodontal disease
Bleeding gums
Bad breath
Gums recede
The Pathogenesis is____
Calcium salts (Dental Calculus)
Causes gingivitis
Bacteria release Hyaluronidase & Collagenase to disolve periodontal ligaments
Gastritis which can lead to Ulcers
And produces dark colored stool is from the organism
Helicobacter pylori
Which bacteria can be found in humans and well water
H. Pylori
Mumps, Rubeola, and RSV all share…
paramyxovirus
This virus can enter the Parotid Gland, Meninges, Testies, Ovaries, Pancreas
(GI tract infection)
Mumps (paramyxovirus)
After having mumps (paramyxovirus) does a person develop immunity
(GI tract infection)
Yes
Cholera has an AB exotoxin which…
A: (Entreotoxin) forces intestinal cells to pump out water and electrolytes
B: Binds
Salmonella requires a high or low amount of organisms to create an infection
High
Salmonella bacterial _____ allow entry into epithelial cells
Secretion system
Most common water born illness in USA
Giardia Lamblia
Giardia lamblia can be passed from person to person and has a (high / low) amount of organisms needed for infection
Low