ch 22 the respiratory system Flashcards
respiration: gas exchange
respiratory system
organ system that takes in air and expels it from the body
respiration: gas exchange
respiration
refers to ventilation of the lungs (breathing)
respiration
gas exchange
O2 and CO2 exchanged between blood and air
respiration
communication
speech and other vocalizations
respiration
olfaction
sense of smell
respiration
acid-base balance
influences pH of body fluids by eliminating CO2
respiration
blood pressure regulation
assists with synthesis of angiotensin II
a hormone that regulates blood pressure
respiration
blood and lymph flow
breathing creates pressure gradients between thorax and abdomen
respiration
platelet production
more than 1/2 of platelets are made by megakaryocytes in lungs
not in bone marrow
respiration
blood filtration
lungs filter small clots
respiration
expulsion of abdominal contents
breath-holding assists in urination, defecation, childbirth
organization of respiratory organs
principal organs of the respiratory system
- nose
- pharynx
- larynx
- trachea
- bronchi
- lungs
organization of respiratory organs
conducting zone
passages that serve only for airflow
(no gas exchange)
* nostrils through major bronchioles
organization of respiratory organs
respiratory zone
regions that participate in gas exchange
* alveoli and nearby structures
organization of respiratory organs
upper respiratory tract
airway from nose through larynx
organization of respiratory organs
lower respiratory tract
regions from trachea through lungs
structure of the nose
nasal mucosa covered by a
respiratory epithelium
structure of the nose: respiratory epithelium
ciliated pseudostratified columnar epithelium contains what kind of cells
- goblet cells
- ciliated cells
strucutre of the nose: respiratory epithelium
goblet cells
produce most of the mucus, supplemented by mucous glands in lamina properia
strucuture of the nose: respiratory epithelium
ciliated cells
have motile cilia that propel the mucus posteriorly toward pharynx to be swallowed
strucuture of the nose:
olfactory epithelium
is involved in the sense of smell
strucuture of the nose: olfactory epithelium
located at roof of each
nasal fossa
strucuture of the nose: olfactory epithelium
immobile cilia bind
odarant molecules
do not propel nucleus
strucuture of the nose: olfactory epithelium
olfactory glands secrete serous fluid to assist
diffusion of odor molecules to receptors on the cilia
the pharynx
pharynx
muscular funnel extending about 13 cm (5 inch) from posterior nasal apertures to larynx
divided into 3 regions
the pharynx
nasopharynx
posterior to nasal apertures and above soft palate
the pharynx: nasaopharynx
receives auditory tubes and contains
pharyngeal tonsil
the pharynx: nasaopharynx
90 degrees downward turn
traps large particles
the pharynx: oropharynx
space between
soft palate and epiglottis
* contains palatine tonsils
the pharynx: laryngopharynx
posterior to
larynx, from epiglottis to cricioid cartilage
* esophagus begins at that points
the larynx
cartilaginous chamber about
4 cm (1.5 inch) long
the larynx
primary function is to keep
food and drink out of airway
the larynx
also involved in
production of sound
* commonly known as “voice box”
epiglottis
flap of tissue that guards
superior opening of larynx
epiglottis
at rest stands almost
vertically
epiglottis
during swallowing, extrinsic muscles pull
larynx upward
epiglottis
tongue pushes epiglottis down to
meet it
epiglottis
closes airway and directs food to
esophagus behind it
epiglottis
vestibular folds of the larynx play greater role in keeping
food and drink out of the airway
cartilages of the epiglottis
nine cartilages make up framework of
larynx
cartilages of the epiglottis
first 3 are
solitary and relatively large
cartilages of the epiglottis
epiglottic cartilage
- most superior
- spoon-shaped supportive plate in epiglottis
cartilages of the epiglottis
thyroid cartilage
- shield-shaped and largest laryngeal cartilage
- contains laryngeal prominence (Adam’s Apple)
- testosterone stimulates growth, larger in males
cartilages of the epiglottis
cricoid cartilage
- ring-like shape
- connects larynx to trachea
cartilages of the epiglottis
what are the first 3 cartilages of the epiglottis
- epiglottic cartilage
- thyroid cartilage
- cricoid cartilage
cartilages of the epiglottis
what are the 3 smaller, paired cartilages
- arytenoid cartilages
- corniculate cartilages
- cuneiform cartilages
cartilages of the epiglottis
arytenoid cartilages
posterior to thyroid cartilage
cartilages of the epiglottis
corniculate cartilages
attached to arytenoid cartilages like a pair of little horns
cartilages of the epiglottis
cuneiform cartilages
support soft tissue between arytenoids and epiglottis
cartilages of the epiglottis
extrinsic ligaments connect the
larynx to external structures
cartilages of the larynx: extrinsic ligaments
thyrohyoid membrane
suspends larynx from hyoid
cartilages of the larynx: extrinsic ligaments
cricothyroid ligament
connects cricoid and thyroid cartilages
cartilages of the larynx: extrinsic ligaments
cricotracheal ligament
suspends trachea from larynx
cartilages of the larynx: extrinsic ligaments
what are the 3 extrinsic ligamnets
- thyrohyoid membrane
- cricothyroid ligament
- cricotracheal ligament
cartilages of the larynx
intrinsic ligamens hold
laryngeal cartilages together
vocal structures
interior wall has 2 folds on each side that extend from
thyroid cartilage in front to arytenoid cartilages in back
vocal structures
vestibular folds
play no role in speech but close the larynx during swallowing
vocal structures: vestibular folds
supported by the
vestibular ligaments
vocal structures
vocal cords
(vocal folds)
produce sound when air passes between them
vocal structures: vocal cords
contain vocal ligaments covered with
stratified squamous epithelium
suited to endure vibration and contact
vocal structures: vocal cords
glottis
the vocal cords and the opening between them
vocal cords
adult male vocal cords when compared to female cords
- usually longer and thicker
- vibrate more slowly
- produce lower-pitched sound
vocal cords
loudness determined by the force of
air passing between the vocal cords
vocal cords
vocal cords produce crude sounds that are formed into words by actions of
- pharynx
- oral cavity
- tongue
- lips
the trachea
tube that connects
larynx to bronchi
commonly called “windpipe”
the trachea: strucure
rigid tube that is how long and what is the diameter
12 cm (4.5 inch) long
2.5 cm (1 inch) in diameter
the trachea: strucure
supported by
16 to 20 C-shaped rings of hyaline cartilage
* prevents collapse during inhalation
the trachea: strucure
opening in cartilage rings faces
posteriorly toward esophagus
* allows esophagus to expand as swallowed food passes by
the trachea: strucure
trachealis
muscle spans opening in rings
* contracts or relaxes to adjust airflow
the trachea: strucure
carina
lowermost tracheal cartilage has internal median ridge
the trachea: histology
lined by
pseudostratified columnar epithelium
trachea: histology of pseudostratified columnar epithelium
contains
- mucus-secreting cells
- ciliated cells
- stem cells
trachea: histology of pseudostratified columnar epithelium
mucociliary escalator
- mechanism for debris removal
- mucus traps inhaled particles, upward beating cilia moves mucus to pharynx to be swallowed
trachea: histology
connective tissue beneath the tracheal epithelium contains
- lymphoid nodules
- mucous and serous glands
- tracheal cartilages
trachea: histology
adventitia
- outermost layer of trachea
- fibroud connective tissue that blends into adventitia of other nearby organs (esophagus)
tracheotomy
tracheotomy
to make a temporary opening in the trachea and insert a tube to allow airflow
tracheotomy
prevents asphyxiation due to
upper airway obstruction
tracheotomy
potential problems include
- inhaled air bypasses the nasal cavity and is hot humidified
- if left for long, will dry out mucous membrane
- become encrusted and interfere with clearance of mucus from tract, thereby promoting infection
tracheotomy
intubation
when a patient is on a ventilator air is introduced directly into trachea
* air must be filtered and humidified
lungs and bronchial tree
each lung is a conical organ with the following landmarks
- base
- apex
- costal surface
- mediastinal surface
- hilum
- root of lung
lungs and bronchial tree
base
broad concave portion resting on diaphragm
lungs and bronchial tree
apex
tip that projects just above the clavicle
lungs and bronchial tree
costal surface
pressed against the ribcage
lungs and bronchial tree
mediastinal surface
faces medially toward the heart
lungs and bronchial tree
hilum
slit through which the lung receives the
* main bronchus
* blood vessels
* lymphatics
* nerves
lungs and bronchial tree
strucutures near hilum constitute
root of lung
lungs and bronchial tree
left and right lungs are not
symmetrical
lungs and bronchial tree: right lung
shorter than left because
liver rises higher on the right
lungs and bronchial tree: right lung
has 3 lobes
- superior
- middle
- inferior
lungs and bronchial tree: right lung
horizontal fissure
seperated superior and middle lobes
lungs and bronchial tree: right lung
oblique fissure
seperates middle and inferior lobes
lungs and bronchial tree: left lung
tall and narrow because the heart
tilts toward the left and occupies more space on this side of mediastinum
lungs and bronchial tree: left lung
cardiac impression
has indentation to accommodate heart
lungs and bronchial tree: left lung
has 2 lobes
- superior and inferior lobes
- seperated by a single oblique fissure
lungs and bronchial tree
bronchial tree
a branching system of air tubes in each lung
lungs and bronchial tree: bronchial tree
extends from main bronchus to
65,000 terminal bronchioles
lungs and bronchial tree
main (primary) bronchi arise from
fork of trachea
lungs and bronchial tree: main (primary) bronchi
right main bronchus
is wider and more vertical than left main bronchus
* right is 2 to 3 cm long, left about 5 cm long
lungs and bronchial tree: main (primary) bronchi
aspirated (inhaled) foreign objects lodge in the
right main bronchus more often than in the left
lungs and bronchial tree
the main bronchi divide into
lobar (secondary) bronchi
lungs and bronchial tree: lobar (secondary) bronchi
a lobar bronchus serves each
lobe of each lung
lungs and bronchial tree: lobar (secondary) bronchi
right main bronchus gives off 3 branches
- superior
- middle
- inferior lobar bronchi
lungs and bronchial tree: lobar (secondary) bronchi
left main bronchus gives off 2 branches
- superior
- inferior lobar bronchi
lungs and bronchial tree
lobar bronchi branch into
segmental (tertiary) bronchi
lungs and bronchial tree: segmental (tertiary) bronchi
segmental (tertiary) bronchi
- 10 in right lung
- 8 in left lung
lungs and bronchial tree: segmental (tertiary) bronchi
bronchopulmonary segment
functionally independent unit of lung ventilated by segmental bronchus
lungs and bronchial tree
bronchioles
continuations of airway that lack supportive cartilage and are 1mm or less in diameter
lungs and bronchial tree: bronchioles
pulmonary lobule
portion of lung ventilated by one bronchiole
lungs and bronchial tree: bronchioles
have ciliated cuboidal epithelium and
well-developed layer of smooth muscle
lungs and bronchial tree: bronchioles
each bronchiole into
50 to 80 terminal bronchiles
lungs and bronchial tree: terminal bronchioles
final branches of
conducting zone
lungs and bronchial tree: terminal bronchioles
measure 0.5 mm or
less in diameter
lungs and bronchial tree: terminal bronchioles
have no mucous
glands or goblet cells
lungs and bronchial tree: terminal bronchioles
have cilia that move mucus by
mucociliary escalator
lungs and bronchial tree: terminal bronchioles
each terminal bronchiole gives off
2 or more smaller respiratory bronchioles
lungs and bronchial tree: respiratory bronchioles
these have alveoli budding from their
walls
lungs and bronchial tree: respiratory bronchioles
considered the beginning of the respiratory zone since the
alveoli participate in gas exchange
lungs and bronchial tree: respiratory bronchioles
each respiratory bronchiole divides into
2 to 10 alveolar ducts
lungs and bronchial tree: respiratory bronchioles
elongated thin-walled passages with
alveoli along their walls
lungs and bronchial tree: respiratory bronchioles
end in alveolar sacs
clusters of alveoli around a central space (atrium)
lungs and bronchial tree
alveoli
microscopic air pouches in the lungs
each about 0.2 to 0.5 mm in diameter
lungs and bronchial tree: alveoli
480 million alveoli in each
lung
providing 70 msquared of surface for gas exchange
lungs and bronchial tree: alveoli
cells of the alveoli
- squamous (type 1) alveolar cells
- great (type 2) alveolar cells
- alveolar macrophages (dust cells)
lungs and bronchial tree: cells of the alveoli
squamous (type 1) alveolar cells
- thin cells allow rapid gas diffusion between air and blood
- cover 95% of alveolus surface area
lungs and bronchi tree: cells of the alveoli
great (type 2) alveolar cells
- round to cuboidal cells that cover the remaining 5% of alveolar surface
- repair the alveolar epithelium when the squamous (type 1) cells are damaged
- secrete pulmonary surfactant
lungs and bronchi tree: cells of the alveoli–> great alveolar cells
pulmonary surfactant
mixture of phospholipids and proteins that coats the alveoli and prevents them from collapsing during exhalation
lungs and bronchi tree: cells of the alveoli: alveolar macrophages
alveolar macrophages
(dust cells)
- most numerour of all cells in the lung
- wander lumens of alveoli and connective tissue between them
- keep alveoli free from debris by phagocytizing dust particles
- millions of dust cells die each day as they ride up the mucociliary escalator to be swallowed and digested with their load of debris
lungs and bronchi tree:
respiratory membrane
thin barrier between the alveolar air and blood
lungs and bronchi tree: respiratory membrane
each alveolus surrounded by a basket of
capillaries supplied by the pulmonary artery
lungs and bronchi tree: respiratory membrane
gases exchanged across respiratory membrane which
consists of 3 layers
lungs and bronchi tree: respiratory membrane
3 layers
- sqamous alveolar cells
- endothelial cells of blood capillary
- their shared basement membrane
pulmomary circulation
lungs receive both
pulmonary and systemic blood supplies
pulmomary circulation
pulmonary circuit
- pulmonary trunk
- pulmonary arteries
- lobar arteries
- capillaries surrounding alveoli
- pulmonary veins
pulmomary circulation: pulmonary circuit
serves to unload carbon dioxide from blood so it can be
exhaled and pick up oxygen from inhaled air
pulmomary circulation:
systemic blood supply
- bronchial arteries arise from aorta
- supply lung tissue (pleura, bronchi, bronchioles, larger vessels) with blood supply
pulmomary circulation: systemic blood supply
bronchial veins drain this blood into
azygos vein of thorax
pulmomary circulation
right-to-left shunt
some bronchial venous blood mixes with pulmonary venous blood
* dilutes oxygen contetn somewhat
pulmomary circulation
gases diffuse too slowly through
liquid to sufficiently aerate the blood
pulmomary circulation: to prevent fluid accumulation
alveoli are kept dry by
low blood pressure in capillaries
pulmomary circulation: to prevent fluid accumulation
mean blood pressure is
10 mm Hg
(compared to 30 mm Hg at the arterial end of the average capillary elsewhere)
pulmomary circulation: to prevent fluid accumulation
reabsorption (osmotic uptake of water) overrides
filtration and keeps the alveoli free of excess fluid
* the low capillary blood pressure also prevents rupture of the delicate respiratory membrane
pulmomary circulation: to prevent fluid accumulation
lungs have more extensive lymphatic drainage than any other
organ in the body
the pleurae
pleura
serous membrane that lines thoracic wall and forms surface of lung
the pleurae
visceral pleura
forms surface of the lung
the pleurae
parietal pleura
adheres to
* mediastinum
* inner surface of the rib cage
* superior surface of the diaphragm
the pleurae
pleural cavity
potential space between pleurae
the pleurae: the pleural cavity
normally no room between the membrances, but contains a film of
slippery pleural fluid
the pleurae: the pleural cavity
pleural effusion
pathological seepage of fluid into the pleural cavity
functions of pleurae and pleural fluid
reduction of friction
allow lungs to move with minimal friction
functions of pleurae and pleural fluid
creation of a pressure gradient
pressure gradient assists with lung inflation
functions of pleurae and pleural fluid
compartmentalization
prevents spread of infection from one organ in mediastinum to others
pulmonary ventilation: breathing
breathing is a repetitive cycle of
inspiration (inhaling) anf expiration (exhaling)
pulmonary ventilation: breathing
respiratory cycle
one complete breath
inspiration and expiration
pulmonary ventilation: breathing
quiett respiration
breathing while at rest
effortless and automatic
pulmonary ventilation: breathing
forced respiration
deep or rapid breathing such as during exercise or playing an instrument
pulmonary ventilation: breathing
flow of air in and out of lung depends on a
pressure difference between air within lungs and outside body
pulmonary ventilation: breathing
respiratory muscles change
lung volumes and create differences in pressure relative to the atmosphere
respiratory muscles
principal muscles of respiration are the
diaphragm and intercostal muscles
respiratory muscles
diaphragm
prime mover of respiration
respiratory muscles: diaphragm
contraction flattens diaphragm enlarging
thoracic cavity and pulling air into lungs
respiratory muscles: diaphragm
relaxation allows diaphragm to bulge
upward again compressing the lungs and expelling air
respiratory muscles: diaphragm
accounts for 2/3 of
airflow
respiratory muscles
internal and external intercostal muscles
assist diaphragm
respiratory muscles: internal & external intercostal muscles
located between
ribs
respiratory muscles: internal & external intercostal muscles
contribute to enlargements and contraction of
thoracic cage
respiratory muscles: internal & external intercostal muscles
add about 1/3 of the air that ventilates the
lungs
respiratory muscles:
accessory muscles of respiration act mainly in
forced respiration
respiratory muscles:
accessory muscles of respiration include
- sternocleidomastoid
- pectoralis major
- pectorlais minor
- erector spinae
- scalenes
- serratus anterior
- serratus posterior superior muscles
respiratory muscles: accessory muscles
aid in
deep inspiration
respiratory muscles:
normal quiet expiration
energy-saving passive process
achieved by the elasticity of the lungs and thoracic cage
* As muscles relax, structures recoil to original shape and original
(smaller) size of thoracic cavity
* Results in airflow out of lungs
The Respiratory Muscles
Forced expiration:
- Rectus abdominis, internal intercostals, and other lumbar,
abdominal, and pelvic muscles - Greatly increased abdominal pressure pushes viscera up against
diaphragm increasing thoracic pressure, forcing air out
The Respiratory Muscles
Valsalva maneuver
breathing technique used to help
expel contents of certain abdominal organs
Neural Control of Breathing
Breathing depends on repetitive stimulation of skeletal
muscles from brain and will cease if spinal cord is severed
high in neck
- Skeletal muscles require nervous stimulation
- Multiple respiratory muscles require coordination
Neural Control of Breathing
Breathing is controlled at two levels of the brain
- One is cerebral and conscious
- Other is unconscious and automatic
Neural Control of Breathing
Brainstem respiratory centers
- Automatic, unconscious breathing is controlled by
respiratory centers in reticular formation (medulla
oblongata and pons) - Two pairs of respiratory centers in the medulla and one
pair in pons
Neural Control of Breathing: brainstem respiratory centers
Ventral respiratory group (VRG)
- In medulla
- Primary generator of the respiratory rhythm
- Reverberating circuits of inspiratory (I) neurons and expiratory
(E) neurons - Produces a respiratory rhythm of 12 breaths per minute
Neural Control of Breathing: Brainstem respiratory centers
Dorsal respiratory group (DRG)
- In medulla
- Modifies the rate and depth of breathing
- Receives influences from external sources (pons, medulla,
receptors in lungs, and higher brain centers