ch. 19 pacemaker Flashcards
19.4b Pacemaker Physiology
SA node fires spontaneously at
regular intervals
pacemaker mechanism
SA node does not have a stable
resting membrane potential
pacemaker mechanism
starts at -60mV and drifts upward due to slow
Na+ inflow this gradual depolarization is the pacemaker potential (prepotential)
pacemaker mechanism
When it reaches threshold of -40mV voltage gated Ca2+ and Na+ channels
Open
Faster depolarization occurs peaking at 0mV
pacemaker mechanism
K+ channels then open and K+ leaves the
Cell causing repolarization
Once K+ channels close pacemaker potential starts over
SA node physiology
When SA node fires it sets off
Heartbeat
As the internal pacemaker it typically fires every 0.8 sec setting the resting rate at 75 bpm