9/16/12 c Flashcards
The less a woman _______ in her lifetime, the lower her chance of developing ovarian cancer.
ovulates
What are the neoplastic cells in multiple myeloma? What is secreted by these cells?
B-cells –> plasma cells; Ig (or Ig light chain)
What are the effects of multiple myeloma on other blood cells? MSK? Kidneys?
normocytic normochromic anemia;
lytic bone lesions –> back pain, path. fractures;
kidney failure due to hypercalcemia and AL amyloid
What are the findings of multiple myeloma in the peripheral blood smear?
erythrocyte roleaux formation
What are the classic findings of multiple myeloma in the urine?
Bence-Jones protein
What is Bence-Jones protein (makes up AL amyloid)?
Ig light chains
What 2 diseases can AL amyloidosis indicate?
multiple myeloma or Waldenstrom’s macroglobulinemia
What are the neoplastic cells in Waldenstrom’s macroglobulinemia? What is secreted by these cells?
B-cells; IgM
Pt w/ hematologic malignancy presents with facial/periorbital pain, headaches, and purulent nasal discharge. Biopsy of paranasal sinus shows fungi w/ broad, non-septate hyphae branching at wide angles. Dx? Tx?
Mucormycosis. Amphotericin B and debridement.
Smoking most greatly increases the risk of developing _______, the #1 killer of the asbestos-exposed population.
bronchogenic carcinoma
Asbestosis is characterized by the development of fibrocalcific plaques in the _______.
parietal pleura
What are asbestos bodies composed of?
asbestos fibers coated with a protein-iron matrix
What is the most common primary cardiac tumor in children?
rhabdomyoma
What are the 2 dominant cardiac anomolies in DiGeorge syndrome?
ToF; aortic arch anomalies
What cardiac condition is sometimes associated w/ Friedreich’s ataxia?
hypertrophic cardiomyopathy
