8/25/12 Flashcards
What disease do you find anit-mitochondrial Ab’s?
Primary biliary cirrhosis
In what disease do you find Ab’s against centromeres?
CREST
In what disease do you find anti-histone Ab’s?
Lupus, esp. Drug-Induced
In what disease do you find Ab’s that react with sheep RBCs?
EBV (Monospot test)
In what disease do you find anti-dsDNA Ab’s?
SLE
What are the main chemoattractants for neutrophils?
bacterial products and CILK C5a IL-8 LT-B4 Kallikrein
What is an infectious cause of achalasia in Central and South America?
Trypanosoma cruzi (Chagas disease)
A patient from the northeastern U.S. presents with a malaria-like illness. No recent travel to malaria-infested areas. What do you suspect? What co-infection would you test for?
Babesiosis. Check for Lyme disease co-infection.
What disease does toxoplasmosis resemble in immunocompetent hosts?
mononucleosis
What does Chagas disease destroy? What are the manifestations?
myenteric plexuses of the esophagus, GI tract, and ureters - achalasia, megacolon, megaureter
The CFTR protein is a _______-gated chloride channel.
ATP
What is haptoglobin?
It binds hemoglobin from lysed RBC’s and carries it to the reticuloendothelial system of the spleen to be destroyed.
What does a low serum haptoglobin level indicate?
Hemolysis (e.g. hemolytic anemias)
What do schistocytes (helmet cells) indicate?
Intravascular hemolysis, as from TTP-HUS, DIC, or prosthetic valves.
What renal pathology is sometimes caused by beta-lactam Abx, NSAIDs, sulfonamides, rifampin, or diuretics?
Acute Interstitial Nephritis
