9/1/12 Flashcards
What are the 2 functions of C1 esterase inhibitor?
suppress activation of early complement; inactivate kallikrein
What diagnosis is a low level of C1 esterase inhibitor indicative of?
hereditary angioedema
What drugs are contraindicated in a pt w/ low levels of C1 esterase inhibitor?
ACE-I’s
Palpable but nontender gallbladder (Courvoisier’s sign) + obstructive jaundice + weight loss =
adenocarcinoma of the head of the pancreas compressing the common bile duct
Friedrich’s ataxia is associated w/ what CV defect?
hypertrophic cardiomyopathy
What cardiac defect is associated with tuberous sclerosis?
rhabdomyoma
Name 2 neuroendocrine tumor markers.
Chromogranin A and neuron specific enolase
What is chlorpromazine?
Typical antipsychotic (aka Thorazine)
What is fluoxetine?
Prozac! (an SSRI)
What vitamin helps when supplemented in measles infection?
Vit A
70% of pt’s w/ MEN I have GI tumors that secrete _______. (This condition is called _______.)
gastrin; Zollinger-Ellison syndrome
What is the mechanism of anemia and low levels of WBC’s or plt’s in SLE?
Peripheral destruction due to auto-antibodies.
What inherited condition may cause bone marrow hypoplasia/aplasia?
Fanconi’s anemia
Will treating GAS pharyngitis early prevent PSGN?
nope
Will treating GAS pahryngitis early prevent rheumatic fever?
yes!
What do zafirlukast and motelukast target?
LT-D4 receptors
What substance causes the increase in renal filtration fraction in hypovolemia?
Ang II
Is pulmonary embolism associated w/ respiratory acidosis or alkalosis? Why? Will PaCO2 be high or low?
alkalosis; hyperventilation; high
What is the difference between myoclonus and dystonia?
myoclonus is brief; dystonia is sustained
What are the cardiac effects of TCA toxicity?
bradycardia; prolonged QT; premature ventricular beats, hypotension
What is the best pharmacological tx for TCA cardiotoxicity?
bicarb
How do TCA’s (in overdose) cause their cardiotoxic effects?
inhibition of fast Na+ channels (prolongs QRS, at risk for arrrhythmias).
