9/1/12

Question 1

What are the 2 functions of C1 esterase inhibitor?

Answer 1

suppress activation of early complement; inactivate kallikrein

Question 2

What diagnosis is a low level of C1 esterase inhibitor indicative of?

Answer 2

hereditary angioedema

Question 3

What drugs are contraindicated in a pt w/ low levels of C1 esterase inhibitor?

Answer 3

ACE-I’s

Question 4

Palpable but nontender gallbladder (Courvoisier’s sign) + obstructive jaundice + weight loss =

Answer 4

adenocarcinoma of the head of the pancreas compressing the common bile duct

Question 5

Friedrich’s ataxia is associated w/ what CV defect?

Answer 5

hypertrophic cardiomyopathy

Question 6

What cardiac defect is associated with tuberous sclerosis?

Answer 6

rhabdomyoma

Question 7

Name 2 neuroendocrine tumor markers.

Answer 7

Chromogranin A and neuron specific enolase

Question 8

What is chlorpromazine?

Answer 8

Typical antipsychotic (aka Thorazine)

Question 9

What is fluoxetine?

Answer 9

Prozac! (an SSRI)

Question 10

What vitamin helps when supplemented in measles infection?

Answer 10

Vit A

Question 11

70% of pt’s w/ MEN I have GI tumors that secrete _______. (This condition is called _______.)

Answer 11

gastrin; Zollinger-Ellison syndrome

Question 12

What is the mechanism of anemia and low levels of WBC’s or plt’s in SLE?

Answer 12

Peripheral destruction due to auto-antibodies.

Question 13

What inherited condition may cause bone marrow hypoplasia/aplasia?

Answer 13

Fanconi’s anemia

Question 14

Will treating GAS pharyngitis early prevent PSGN?

Answer 14

nope

Question 15

Will treating GAS pahryngitis early prevent rheumatic fever?

Answer 15

yes!

Question 16

What do zafirlukast and motelukast target?

Answer 16

LT-D4 receptors

Question 17

What substance causes the increase in renal filtration fraction in hypovolemia?

Answer 17

Ang II

Question 18

Is pulmonary embolism associated w/ respiratory acidosis or alkalosis? Why? Will PaCO2 be high or low?

Answer 18

alkalosis; hyperventilation; high

Question 19

What is the difference between myoclonus and dystonia?

Answer 19

myoclonus is brief; dystonia is sustained

Question 20

What are the cardiac effects of TCA toxicity?

Answer 20

bradycardia; prolonged QT; premature ventricular beats, hypotension

Question 21

What is the best pharmacological tx for TCA cardiotoxicity?

Answer 21

bicarb

Question 22

How do TCA’s (in overdose) cause their cardiotoxic effects?

Answer 22

inhibition of fast Na+ channels (prolongs QRS, at risk for arrrhythmias).