8/21/12 Flashcards
What is bromocryptine?
dopamine agonist used in idiopathic Parkinson’s disease
What is benztropine?
a centrally-acting anticholinergic used on Parkinson’s
Vimentin is a marker for cells of _______ origin. Therefore the type of malignancy they may be found in is ________.
mesenchymal; sarcomas
Does the cardiac cycle represented on the pressure-volume loop run clockwise or counter-clockwise? What does the bottom line represent?
counter-clockwise; diastolic filling
What does the right vertical line represent in the cardiac pressure-volume loop?
isovolumetric contraction
What does the top (curved) line represent in the cardiac pressure volume loop?
ventricular ejection
What does the left vertical line of the cardiac pressure-volue loop represent?
isovolumetric relaxation
What is the effect of an A-V shunt on the cardiac cycle?
increased EDV and decreased pressure of ventricular ejection (b/c pressure of shunt is less than that of arterioles)
What reactions require tetrahydrobiopterin as a cofactor?
Phe->Tyr->DOPA, dopamine, NE, Epi, melatonin
Trp->5-HT, serotonin
NO synth
Most cases of PKU are caused by a deficiency of _______, but a minority are caused by a deficiency of _______.
Phe hydroxylase; dihydrobiopterin reductase
The c-myc protein, associated w/ _______, functions as a _______.
Burkitt’s lymphoma; transcription activator
2 ways to protect from cisplatin nephrotoxicity.
amifostine or chlotide diuresis (by IV saline)
does the valsalva maneuver increase or decrease preload?
decrease
Do murmurs of hypertrophic cardiomyopathy increase or decrease in volume with decreased prelload?
increase in volume (less LV volume to overcome outfolw tract obstruction)
Who is the typical pt w/ Buerger’s disease (thromboangiitis obliterans)?
heavy smoker under 35 - Asian, Israeli
