8/20/12 Flashcards

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1
Q

What does a positive VDRL test in a lupus pt generally indicate?

A

APLA (+)

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2
Q

What is APLA’s effect on coagulability?

A

causes hypercoaulable state.

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3
Q

What two hormones are commonly released ectopically by small cell carcinoma of the lung?

A

ADH and ACTH

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4
Q

How would blood chemistry change as a result of SIADH? Urine?

A

Blood: hyponatremia, low osmolality
Urine: high osmolality (concentrated)

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5
Q

What is the mechanism by which SIADH causes hyponatremia?

A

Normal to increased blood volume suppresses the Renin-Angiotensin-Aldosterone axis and prevents aldo from conserving Na+.

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6
Q

What is the antidote for heparin overdose?

A

Protamine sulfate

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7
Q

Which defect is the major determining factor in the degree of cyanosis in Tetralogy of Fallot?

A

degree of pulmonic stenosis

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8
Q

Late complement deficiencies lead to recurrent infections with _______.

A

Neisseria

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9
Q

Which drugs are methylxanthines?

A

the “-phyllines”, e.g. theophylline, aminophylline

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10
Q

What is the mechanism of action of methylxanthines in asthma tx?

A
  1. phosphodiesterase inhibition increases cAMP in smooth muscle
  2. they block adenosine receptors
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11
Q

Which diuretics increase calcium excretion?

A

Furosemide (loop diuretics) and acetazolamide (inhibits sodium and calcum reabsorption at the proximal tubule)

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12
Q

Dislocation of the shoulder is most likely to damage which nerve? Which 2 muscles might be weakened?

A

Axillary n. - deltoid and teres minor mm.

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13
Q

Which 2 nerves innervate all of the intrinsic mm. of the hand?

A

median and ulnar nn.

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14
Q

“Waiter’s tip” results from injury to which nerve roots?

A

C5-6 (Erb’s Palsy)

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15
Q

left-sided varicocele + flank pain + hematuria =

A

left renal vein occlusion by thrombus or malignant tumor

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16
Q

How can nephrotic syndrome lead to thrombosis?

A

loss of anti-coagulant factors like antithrombin III

17
Q

Which is more likly to progress to colon carcinoma, a pedunculated or a sessile polyp? Tubular or villous histology?

A

sessile, villous

18
Q

Which 2 cancers most typically release PTHrP?

A

Squamous cell lung carc., breast carc.