05/16/2023 Notes Flashcards
What is ossification (osteogenesis)?
Formation and development of bone connective tissue
What are the two methods of ossification?
Intramembranous Ossification and Endochondral Ossification
What bones are formed from intramembranous ossification?
Flat bones of the skull, zygomatic bones, maxilla, mandible, central part of clavicle, and sesamoid bones
What form of ossification forms the majority of the skeleton (upper and lower limbs, pelvis, vertebrae, and ends of clavicles)?
Endochondral Ossification
During the first 8-12 weeks of fetal development, the hyaline cartilage model is formed from what?
Chondroblasts that secrete cartilage matrix
Cartilage cells in the center of the shaft increase in size and minerals are deposited via…?
Calcification
What is the periosteal bone collar?
A thin plate of bone that surrounds the cartilage during the initial steps of calcification in the hyaline cartilage model
What is the primary ossification center
A region where bone replaces cartilage in the center of the diaphysis of the hyaline cartilage and starts bone development in both directions to the epiphyses
What are secondary ossification centers?
Similar to the primary ossification centers, but occurs in the proximal and distal epiphysis
Calcification continues until what cartilage remains in the hyaline cartilage model?
Articular cartilage and hyaline cartilage found in epiphyseal growth plates
Bone will grow in _____ as long as there is mitotic activity in the hyaline cartilage
Length
Around the ages of _____, epiphyseal growth plates will ossify and leave behind _____?
18-20; epiphyseal line
Is bone remodeling a continuous process?
Yes, it occurs throughout a person’s lifetime
What causes the growth of bone tissue in width?
Pulling on the periosteum which activates osteoblasts to secrete osteoid
How were Roman soldiers identified in the remains of Pompeii?
Their left arm bones were thickened from carrying shields
How do braces work in straightening teeth?
Activate osteoclasts and osteoblasts from the stress of tightening wires
What allows the entry of blood vessels and nerves into the bone?
Nutrient Foramen
Blood vessels that enter the bone through the nutrient foramen do what?
Bring oxygen and nutrients to the metabolically-active bone cells
What detects and signals injuries to the bone?
Nerves
What two hormones stimulate epiphyseal growth plates?
Growth hormone (somatotropin) and Sex hormones (testosterone/estrogen)
Where is somatotropin produced?
In the anterior portion of the pituitary gland
What hormones are secreted in great amounts during puberty that dramatically accelerates bone growth at epiphyseal growth plates?
Estrogen and Testosterone
What three vitamins have an effect on bone growth?
Vitamin A, C, and D
What vitamin activates osteoblasts?
Vitamin A
What does Vitamin C do to bones?
It is required for the synthesis of collagen
Vitamin D stimulates the absorption and transports what molecules?
Calcium and phosphate ions
A lack of Vitamin D in children can result in what?
Rickets