Zofran (Ondansetron) Flashcards
1
Q
Drug Classification
A
Antiemetic
2
Q
Mechanism of Action
A
5-HT3 (serotonin) R antagonist-> blocks serotonin binding to receptors at vagal nerve terminals-> inhibits vomiting reflex
3
Q
Pharmacokinetics
A
Onset of actions- rapid
Peak Effects- 15-30 minutes
Duration of Effects- 4-8 hours
Half-Life- 4 hours
4
Q
Indications
A
Nausea/Vomiting
5
Q
Contraindications
A
Hypersensitivity
6
Q
Side Effects/Adverse Reactions
A
HA, dizziness, tachycardia, prolonged QT interval
7
Q
Dose
A
Adult
4mg slow IV, IO, may repeat once
Pedi
0.1mg/kg (max 4mg) slow IV, IO
8
Q
Precautions
A
Lower risk of sedation and dystonia than other anti-emetics
9
Q
Drug-Drug interactions
A
Few in EMS
