Adenosine (Adenocard) Flashcards

1
Q

Drug Classification

A

Antidysrhythmic (class V)/nucleoside

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2
Q

Mechanism of Action

A

Adenosine(A1) R agonist->slows AV conduction by activation of G protein second messenger, decreasing cAMP and inhibiting calcium entry into the cardiac pacemaker cells.

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3
Q

Pharmacokinetics

A
  • Onset of Action- immediate
  • Peak Effects- immediate
  • Duration of Effects- 30-45 seconds
  • Half Life- 6 seconds
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4
Q

Indications/Field Use

A
  • SVT (PSVT)/ Narrow Complex Tachycardia
  • Diagnostic maneuver: stable narrow complex SVT
  • Wide regular monomorphic tachycardia
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5
Q

Contraindications

A
  • 2/3 degree heart block, sick sinus syndrome, Torsades (Polymorphic VT)
  • Poison/Chemical induced SVT (ie. Cocaine)
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6
Q

Side Effects/Adverse Reactions

A

Facial Flushing, HA, chest pain, dizziness

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7
Q

Dose

A

Adult:
1st dose- 6mg rapid IVP (proximal vein) followed by 30cc NS flush
2nd dose- 12mg rapid IVP followed by 30cc NS flush

Pedi:
1st dose - 0.1mg/kg IV/IO rapid push (proximal vein), max dose 6 mg
2nd dose - 0.2mg/kg IV/IO rapid push IV/IO rapid push, max dose 12mg

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8
Q

Precautions

A
  • Begin printing rhythm strip before administering adenosine
  • Caution with asthma and COPD- may induce wheezing
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9
Q

Drug-drug interactions

A
  • Methylxanthines (ie. caffeine) are nonspecific competitive antagonists for adenosine receptors- double the dose for patients taking large amounts
  • Carbamazepines (ie. Tegretol, Phenobarbitol) and dipyridamole (Persantine, Aggrenox) potentiates effects of Adenosine- halve the dose
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