Vecuronium (Norcuron)

Question 1

Drug Classification

Answer 1

Non-depolarizing neuromuscular blocker

Question 2

Mechanism of Action

Answer 2

Nicotinic ACh R-antagonist ->competes with ACh at neuromuscular junction and prevents binding thus inhibiting muscle depolarization

Question 3

Pharmacokinetics

Answer 3

• Onset of Action- <1 minute
• Peak Effects- 3-5 minutes
• Duration of Effects- 30-80 minutes
• Half-Life- 30-80 minutes

Question 4

Indications/Field Use

Answer 4

• Need for temporary paralysis to facilitate endotracheal intubation
• Need for continued paralysis following endotracheal intubation

Question 5

Contraindications

Answer 5

Hypersensitivity

Question 6

Side Effects/Adverse Reactions

Answer 6

Bradycardia/hypotension

Question 7

Dose

Answer 7

Adult:
0.08-0.1mg/kg IV/IO
Pedi:
0.1mg/kg IV/IO

Question 8

Precautions

Answer 8

Presence of neuromuscular diseases may be associated with prolonged paralysis

Question 9

Drug-Drug Interactions

Answer 9

Potentiated by lidocaine, procainamide, beta blockers, magnesium sulfate, and other neuromuscular blockers