Metoprolol (Lopressor) Flashcards
1
Q
Drug classification
A
Beta blocker
2
Q
Mechanism of Action
A
Beta 1 receptor antagonist ->inhibits extracellular calcium entry and calcium release from the sarcoplasmic reticulum in cardiac cells -> negative chronotropy, inotropy, dromotropy
3
Q
Pharmacokinetics
A
Onset of action-immediate
Peak effects- 20 minutes
Duration of Effects- 13-19 hours
Half-life- 3-4 hours
4
Q
Indications/Field Use
A
- Rapid ventricular rates associated with a-fib, a-flutter
- PSVT refractory to adenosine
5
Q
Contraindications
A
- hypotension
- decompensated cardiogenic shock
- Suspected cocaine ingestion
6
Q
Side effects/Adverse reactions
A
Bradycardia, hypotension, lethargy, dyspnea, wheezing, dizziness
7
Q
Dose
A
Adult
5mg slow IV/IO q 5 minutes, max total dose 15mg
Pedi
Not for pedi
8
Q
Precautions
A
May exacerbate asthma, COPD, bronchospasm or CHF
9
Q
Drug-Drug interaction
A
- Do not give to pt receiving IV Ca2+ channel blockers, will increase risk of profound bradycardia
- Additive effects with digoxin
