Amiodarone HCL(Cordarone) Flashcards
1
Q
Drug Classification
A
Antidysrhythmic
2
Q
Mechanism of Action
A
- Primary Class III antiarrhythmic/K+ channel blocker-> prolongs phase 3 repolarization and refractory period of ventricular action potential
- Secondary Class 1A antiarrhythmic/Na+ channel blocker-> decreases amplitude of phase 0 depolarization of ventricular action potential
- Secondary Class II antiarrthyhmic/Non competitive Beta blocker
- > Negative chronotropy, inotropy, dromotropy
- Secondary Class IV antiarrhythmic/weak Ca2+ channel blocker
- > negative chronotropy, inotropy, dromotropy
3
Q
Pharmacokinetics
A
Onset of Action- immediate
Peak Effects- 30-45 minutes
Duration of Effects- varies
Half-Life- 40-55 days
4
Q
Indications/Field Use
A
Cardiac Arrest (VF, pulseless VT) Wide Complex Tachycardia
5
Q
Contraindications
A
- Bradycardia
- 2/3 degree heart block
- Hypersensitivity
6
Q
Side Effects/Adverse Reactions
A
Hypotension, bradycardia, dyspnea, cough, dizziness, prolonged PR, QRS, QT intervals
7
Q
Dose
A
Adult:
- VF/Pulseless VT- 300mg IV/IO, repeat dose 150mg IV/IO in 3-5min PRN
- VT with pulse- 150 mg IV/IO over 10 min
- Maintainance- 1mg/min first 6 hours, then 0.5mg/min
Pedi:
- VF/Pulseless VT- 5mg/kg IV/IO; max 300mg, max total dose 15mg/kg
- VT with pulse- 5mg/kg IV/IO, over 20-60min; max 300mg
8
Q
Precautions
A
Caution in patients with heart failure
9
Q
Drug-Drug Interactions
A
- Reduces renal and non-renal clearance of digoxin
- Decreased bio transformation and clearance of warfarin -> enhanced anti-coagulation
- Potentiates procainamide and quinidine
10
Q
Amiodarone Infusion 150mg/10 min
A
Put 150mg into 100 bag
Use 10 drop set= 1.7 drops/sec
Use 15 drop set= 2.5 drops/sec
11
Q
Amiodarone Infusion 150mg/10 min
A
Put 150mg into 100 bag
Use 10 drop set= 1.7 drops/sec
Use 15 drop set= 2.5 drops/sec
