Magnesium Sulfate Flashcards

1
Q

Drug classification

A

Electrolyte/antidysrythmIc

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2
Q

Mechanism of action

A

SMC Ca2+ channel blocker -> inhibits calcium channel entry and the subsequent interaction between actin and myosin in smooth muscle cells-> smooth muscle relaxation and dilation of blood vessels and bronchial tree

CARDIAC Ca2+ channel blocker-> negative chronotropy, inotropy, dromotropy

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3
Q

Pharmacokinetics

Onset of action
Peak effects
Duration of effects
Half life

A
  • Onset of action- immediate IV, 1 hour IM
  • Peak effects- varies
  • Duration of effects- 1 hour
  • Half life- n/a
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4
Q

Indications/field use

A
  • Severe asthma/bronchospasms
  • severe refractory VF or pulseless VT with hypoMg2+, torsades de points
  • eclampsia
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5
Q

Contraindications

A

3rd degree heart block, hypotension

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6
Q

Side effects/adverse reactions

A

Sweating, flushing, itching, rash. Bradycardia, hypotension, drowsiness, respiratory depression. Dysrhythmias

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7
Q

Dose

A

ADULT:
Asthma: 2g in 100cc NS IV/IO infusion over 10 minutes
VT/VF/Torsades no pulse: 2g IV/IO over 1-2 minutes
VT/Torsades with pulse: 1-2g in 50-100cc NS IV/IO over 5-60 minutes
Eclampsia- 4g in 20mL IV/IO over 5 minutes

PEDI:
Asthma- 25-50 mg/kg IV/IO infusion over 15-30 min MAX DOSE 2g
VT/Torsades no pulse- 25-50mg/kg IV/IO MAX DOSE 2g
VT/Torsades with pulse- 25-50mg/kg IV/IO over 10-20 minutes MAX DOSE 2g

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8
Q

Precautions

A

Caution with impaired renal failure

Watch for respiratory depression

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9
Q

Drug-drug interaction

A

Cardiac conduction abnormalities if given with digitalis

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10
Q

Infusion Sheet

A

Magnesium Sulfate 5g in 10cc= .5g per cc

​Asthma: 2 grams in 100cc over 10 minutes
​VT/VF Torsades without a pulse

2cc from a 10cc vial= 1 gram
4cc from a 10cc vial= 2 grams
8cc from a 10cc vial= 4 grams

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