Albuterol Sulfate proventil HFA, Proair HFA

Question 1

Drug classification

Answer 1

Sympathomimetic/sympathetic agonist (b2 selective)

Question 2

Mechanism of action

Answer 2

B2 agonist-> promotes sympathetic stimulation of bronchial smooth muscle cells, reducing interaction between actin and myosin causing smooth muscle relaxation-> bronchodilation

Question 3

Pharmacokinetics

• onset of action
• peak effects
• duration of effect
• half life

Answer 3

• onset of action-5-15 minutes
• peak effects-1-1.5 hours
• duration of effect- 3-6 hours
• half life- <3 hours

Question 4

Indications/field use

Answer 4

• reversible bronchospasm associated with COPD and asthma

- wheezing associated with allergic reaction/anaphylaxis

Question 5

Contraindications

Answer 5

• Symptomatic tachycardia “my hearts beating out of my chest”
• hypersensitivity

Question 6

Side effects/adverse reactions

Answer 6

Anxiety/nervousness/sweating/tremors

Chest pain/dysrhythmias/palpitations/HTN

HA/Dizziness/N&V

Question 7

Dose

Answer 7

Adult and Pedi

Small Volume Nebulizer- 2.5mg in 2.5mL NS nebulized with oxygen 8lpm

Question 8

Precautions

Answer 8

May worsen cardiac asthma and precipitate dysrhythmias.

Consider 12 lead ECG in patients with associated chest pain

Question 9

Drug-drug interactions:

Answer 9

• Side effects may increase with other sympathetic agonists
• Beta blockers may blunt effects of this drug
• MAOI and TCA may potentiates cardiovascular effects