Fentanyl Citrate (Sublimaze) Flashcards

1
Q

Drug Classification

A

Narcotic Analgesic

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2
Q

Mechanism of Action

A

Opiate R agonist -> Hyperpolarization of interneurons and decreased release of neurotransmitters responsible for the transmission of pain impulses to the thalamus and cerebral cortex

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3
Q

Pharmacokinetics

A
  • Onset of Action- Immediate
  • Peak Effects- 3-5 minutes IV
  • Duration of Effects- 30-60 minutes
  • Half-Life- 6-8 hours
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4
Q

Indications/Field Use

A
  • Severe Pain

- Adjunct for RSI

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5
Q

Contraindications

A
  • Respiratory depression/insufficiency when considering for pain management
  • Uncorrected hypotension
  • Known hypersensitivity
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6
Q

Side Effects/Adverse Reactions

A

Apnea/respiratory depression, bradycardia, chest wall rigidity

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7
Q

Dose

A

Adult:
1mcg/kg slow IV/IO/IN max single dose 100 mcg, repeat after 10 minutes
>65- 0.5mcg/kg slow IV/IO/IN max single dose 50 mcg, repeat in 5 minutes

Pedi:
1-2mcg/kg slow IV/IO/IN

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8
Q

Precautions

A

Caution in patients with kidney and liver dysfunction

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9
Q

Drug-Drug Interactions

A
  • Additive effects with alcohol

- Shouldn’t be given with patients using MAOI in the last 14 days- may cause serotonin syndrome

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