Diazepam (Valium) Flashcards

1
Q

Classification

A

Anticonvulsant/sedative/benzodiazepine/anxiolytic

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2
Q

Mechanism of Action

A

Positive allosteric modulator for GABAa receptors->Binds to benzo receptor site on chloride channels and potentials binding and effects of GABA(increases intracellular Cl- concentration leading to hyperpolarization of the cell

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3
Q

Pharmacokinetics

  • onset of action
  • peak effects
  • duration of effects
  • half life
A
  • Onset of action-1-5 minutes IV, 15-30 minutes IM
  • Peak Effects- 10 minutes IV, 30-45 minutes IM
  • duration of effects- 15-60 minutes
  • half life- 20-50 hours
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4
Q

Indications/field use

A
  • Major motor seizures
  • pre-medication for cardio version or TCP
  • acute anxiety
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5
Q

Contraindications

A

Hypersensitivity

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6
Q

Side effects/adverse reactions

A

Hypotension, hallucinations, drowsiness, amnesia, respiratory depression, blurred vision, AMS, nausea and vomiting(N+V)

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7
Q

Dose

A

Anxiety- adult 2-5mg slow IV, IO
Seizure- adult 5-10mg slow IV, IO
Sedative- 5-15mg slow IV, IO
(PEDI): 0.2mg/kg IV/IO; max dose 5mg

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8
Q

Precautions

A
  • May cause CNS and respiratory depression

- Caution with acute alcohol intoxication -Valium potentiates alcohol

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9
Q

Drug-drug interaction

A

Additive effects with CNS depressants and alcohol

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