Solu-medrol (Methylprednisone)

Question 1

Drug classification

Answer 1

Corticosteroid/anti-inflammatory

Question 2

Mechanism of action

Answer 2

Diffuses across the cell membrane of various cells present in all tissues, binds to DNA, regulates gene expression and increases synthesis of proteins and enzymes that inhibit inflammatory agents (cytokines, interleukins, interferon); inhibits synthesis of pro-inflammatory enzymes

is an immunosuppressant

Question 3

Pharmacokinetics

• onset of action-
• Peak effects-
• duration of effect-
• half life-

Answer 3

• onset of action-2-6 hours
• Peak effects- 4-8 days
• Duration of effect- 1-5 weeks
• half life- 3.5 hours

Question 4

Indications/field use

Answer 4

• allergic reaction/anaphylaxis

- asthma/COPD

Question 5

Contraindications

Answer 5

None EMS

Question 6

Side effects/ adverse reactions

Answer 6

Fluid retention,CHF, HTN, abdominal distension, vertigo, HA, nausea, malaise, hiccups

Question 7

Dose

Answer 7

ADULT
Asthma/anaphylaxis: 125mg slow IV, IO

PEDI
Asthma/anaphylaxis: 2 mg/kg slow IV/IO max 125mg

Question 8

Precautions

Answer 8

Give only one dose prehospitally, long term steroid use can cause GI bleeding, prolonged would healing, and suppression of adrenocortical steroids

Question 9

Drug-drug interactions

Answer 9

• Lasix and thiazides diuretics increase K+ excretion

- Decreased effect with phenytoin, phenobarbital and rifampin due to increased metabolism of steroids