Oxytocin (Pitocin) Flashcards
1
Q
Classification
A
Hormone
2
Q
Mechanism of Action
A
Oxytocin binds to oxytocin receptors in uterine SMC, initiates activity of second messengers, which results in increased intracellular calcium, and in turn promotes contraction of uterine muscle
3
Q
Pharmacokinetics
A
- Onset of Action- immediate IV, 3-7min IM
- Peak Effects- varies
- Duration of Effects- 1 hour IV, 2-3 hours IM
- Half-Life- 3-5 minutes
4
Q
Indications/Field Use
A
Post-partum Hemmorhage
5
Q
Contraindications
A
- Baby and placenta not delivered
- Additional fetus present
If given prior to fetal delivery, fetal hypoxia, asphyxia, intracerebral hemorrhage may occur
6
Q
Side Effects/Adverse Reactions
A
Hypotension, tachycardia, dysrhythmias, seizures, coma, N&V
7
Q
Dose
A
Adult:
- 3-30 units IM
- 10-20 units in 500mL or 1000mL D5W, NS or LR- slow IV/IO infusion
8
Q
Precautions
A
Can cause over-stimulation of uterus and possible uterine rupture- monitor uterine tone
9
Q
Drug-Drug Interactions
A
HTN when given with vasoconstrictors such as NE
