Promethazine (Phenergan) Flashcards
1
Q
Drug Classficiation
A
Antiemetic/Anticholinergic
2
Q
Mechanism of Action
A
H1 (Histamine) and Muscarinic ACh antagonist ->inhibits communication from the chemoreceptor trigger zone (which recognizes emetic toxins) to the vomiting centers of the brain
3
Q
Pharmacokinetics
A
- Onset of Action- 5 minutes IV, 20 minutes IM
- Peak Effects- varies
- Duration of Effects- 4-6 hours
- Half-Life- 10-14 hours
4
Q
Indications/Field Use
A
Nausea/vomiting
5
Q
Contraindications
A
Hypersensitivity
6
Q
Side Effects/Adverse Reactions
A
Dizziness, drowsiness, sedation, blurred vision, bradycardia/tachycardia
7
Q
Dose
A
Adult:
12.5-25mg IV/IM
Pedi:
0.5mg/kg
8
Q
Precautions
A
May cause CNS depression or dystonia
9
Q
Drug-Drug Interactions
A
- Potentiates CNS depressant effect of narcotics, sedatives/hypnotics and alcohol
- Increased incidence of dystonia with concurrent use of MAOI
