Week 8: Chp 30: Pericarditis Flashcards
What is pericarditis?
inflammation of the pericardium
Epidemiology
- not related to ischemia
- 80% of cases are idiopathic (unknown etiology) or are presumed to occur after viral infection
- acute pericarditis is common following MI
- low mortality rate
How can pericarditis be categorized?
-infectious (viral, bacterial, fungal, parasitic)
-noninfectious (autoimmune, neoplastic, metabolic, trauma, and drug related)
idiopathic
>acute, chronic, or recurrent
Pathophysiology of Pericarditis
When the pericardium becomes inflamed
- the heart is surrounded by two-layered pericardium, which protects the heart, reduces friction with surrounding structure, and helps to determine chamber size and pressure
- the tough, fibrous outer wall is the parietal pericardium
- the inner is the visceral pericardium, or epicardium
- the space between the pericardium and the epicardium contains 20 to 60 mL of pericardial fluid; the fluid acts as a lubricant to prevent friction between the 2 layers
- When the pericardium becomes inflamed, it is termed pericarditis
The heart is surrounded by what?
a two-layered pericardium
What does the pericardium do?
protect the heart, reduces friction with surrounding structures, and helps determine chamber size and pressure
What are the two-layers of the pericardium?
- Parietal pericardium: the tough, fibrous outer wall
- Visceral pericardium/ epicardium: inner wall
What is between the parietal pericardium and visceral pericardium/epicardium?
pericardial fluid; acts as a lubricant to prevent friction between the two layers
Clinical Manifestations
- pleuritic chest pain (most common); tends to be relieved by sitting up and leaning forward
- auscultation of friction rub (scratchy sound heard with each heartbeat)
- new or worsening pericardial effusion
- ECG changes: diffuse ST-segment elevations or PR depressions
- fever
Tests For Diagnosis
- ECG
- Chest x-rays
- echocardiogram (transthoracic or transesophageal)
- cardiac CT scan
- MRI
Diagnosis: Electrocardiogram (hallmark changes)
hallmark ECG changes include widespread ST-segment elevation or PR segment depression
Diagnosis: Chest x-ray
the finding of cardiomegaly (enlarged heart) and clear lung fields may indicate pericardial effusion (fluid build up in the pericardial sac) and might be supportive of pericarditis
Pericardial Effusion
fluid buildup in the pericardial sac
- may be found on a chest x-ray
- might be supportive of pericarditis
- might also be evident on an echocardiogram, CT scan, or MRI
- complication of pericarditis
Laboratory Tests
- Serial cardiac biomarkers to rule out MI
- positive blood cultures
- a CBC with a high WBC count
- positive inflammatory markers such a C-reactive protein or
- sedimentation rates may indicate presence of infection or inflammation, leading to the diagnosis of pericarditis when combined with the clinical manifestations
Medication Goals
alleviate pain and stop the inflammatory process
Medications Used
- Aspirin and other NSAIDSs are indicated
- Colchicine may be used as an additional anti-inflammatory with acetylsalicylic acid (ASA) or NSAIDs
- If pain or inflammation is not relieved by ASA or NSAID, corticosteroids may b used
- antimicrobial therapy might be used if bacterial pericarditis
Complications
- pericardial effusion (accumulation of fluid in the pericardial space exceeding the typical 20 to 60 mL)
- pericardial fluid may accumulate slowly (ie. neoplastic), allowing pericardium to stretch to accommodate the increased volume; clinical symptoms progress; rapidly growing effusions overwhelm the stretching capacity of the pericardium, resulting in acute decompensation; if not treated emergently, the increased fluid volume within the pericardial space can exert pressure on the heart resulting in cardiac tamponade
- Cardiac tamponade