Week 6: Asthma: Lower Respiratory Disorder Flashcards
What is Asthma?
- chronic lung disease characterized by intermittent, reversible airway obstruction resulting from inflammation of the lung’s airways and tightening of the muscles that surround the airways
- chronic disorder of the airways that results in intermittent an reversible airflow obstruction of the bronchioles
How does the Obstruction of the airway occur in asthma?
inflammation of the airway or hyperresponsiveness
What does asthma affect?
the bronchial airways, not the alveoli
How is bronchial hyperresponsiveness and underlying inflammation of the small airways triggered by?
-exposure to irritants, exercise, cold weather, or risk factors
Types of Irritants
- cigarette smoke
- mold
- pollen
- dust
- animal dander
- air pollutants
- occupational irritants
- strong odors (perfume)
Risk Factors
- viral infections
- nasal polyps
- allergic rhinitis
- food and medication allergies
- emotional stress
- older adults
- GERD
- family history of asthma
- eczema
- exposure to chemical irritants or dust
What happens when there is an exposure to a trigger?
Inflammatory Response
-IgE antibodies bind to receptors on mast cells, causing degranulation and the release of inflammatory mediators, such as histamine and leukotriene, which cause vasodilation and increase capillary permeability.
-there is edema of the airways and an increase in basophils, eosinophils, and neutrophils, which stimulate the production of mucous
>the resulting thick, tenacious mucous causes a thickening of the airways and bronchial hyperresponsiveness
-the release of histamine causes constriction and spasm of the smooth muscles surrounding the bronchial tubes, causing bronchospasm of the bronchial tubes
>bronchospasms cause further narrowing of the airways
-bronchospasms, mucus production, and edema produce obstruction to the flow of air into and out of the lungs
Clinical Manifestations
- inability to speak in full sentences
- wheezing
- dyspnea
- coughing
- increased sputum
- increased respiratory rate
- chest tightness
- anxiety/stress
- use of accessory muscles
- poor oxygen saturation
- barrel chest or increased chest diameter
- tachycardia
- mucosal edema
- bronchoconstriction
- excessive mucous production
Diagnosis
- detailed patient history
- pulmonary function tests
- chest x-ray
- pule oximetry
- arterial blood gases (ABGs)
Diagnostic Procedures
- pulmonary function tests
- chest-xray
Pulmonary Function Tests (PFTs)
most accurate tests for diagnosing asthma and its severity; group of tests used to evaluate the functioning of the respiratory system
- spirometry
- peak expiratory volume
- pulse oximetry
Pulmonary Function Tests: Spirometry
test that measures airflow and lung volumes such as forced expiratory volume (FEV)
- one of the major tests of pulmonary function is the forced expiratory volume in 1 second (FEV1); measures the amount of air forced out of the lungs after a full inspiration
- a decrease in this test of 15-20% below the predicted value for age and gender is diagnostic of asthma
Pulmonary Function Tests: Peak Expiratory Flow
measure the maximum airflow expired during a forced expiration
- patients peak flow readings are compared to the personal best reading with a reading obtained during an exacerbation or “asthma attack”
- the reading done during an exacerbation as compared to a personal best allows the patient to recognize the severity of the respiratory distress
Pulmonary Function Test: Pulse Oximetry
a non-invasive method of measuring oxygen saturation (SpO2)
-normal value: 95%-100%
Arterial Blood Gas
Invasive sampling of arterial blood to measure the oxygenation of the blood (PaO2)
-provide the best information with regard to identifying the patients response to oxygen and ventilation therapy and medications
PaO2
partial pressure of oxygen in arterial blood
-reflects a more accurate measure of oxygen in arterial blood than SpO2
-once the PaO2 in arterial blood falls below the threshold of 60 mmHg, there is a steep reduction in SpO2
-range: 80-95 mmHg
(even though 60 mmHg is acceptable)
Asthma is classified as?
- mild asthma
- moderate asthma
- severe asthma
- uncontrolled asthma