Week 13: Chp 62: Pyelonephritis Flashcards
Risk factor associated with Pyelonephritis
multiple pre-existing UTIs; treated or untreated
UTIs are caused by
- vesicoureteral reflux, which is a retrograde flow of urine from the bladder to the ureters
- obstructions such as benign prostatic hypertrophy (BPH), a stricture, or a urinary stone
- a long-term indwelling urinary catheter
- pregnancy is implicated in the development of acute pyelonephritis, known as pregnancy-induced acute pyelonephritis, as a result of the physiological changes associated with pregnancy, specifically hormonal changes and anatomical changes that lead to the retention of urine
- sexual activity in women
What is pyelonephritis
inflammation of the renal parenchyma and urinary collecting system
what is the most common cause of pyelonephritis
a bacterial infection that occurs as a result of contamination of the urinary meatus with bacteria found in the GI tract that ascend via the ureters to the renal tissue
-an inflammatory process occurs as a result of the bacterial invasion of the renal parenchyma
Most common bacteria to cause pyelonephritis
Escherichia coli
Clinical manifestations
-signs of infection: fever, chills, nausea, and vomiting
-back or flank pain
-costovertebral tenderness and enlarged kidneys are noted by palpation on physical examination
-may also present with symptoms of a UTI: frequent and painful urination and hematuria
-
What are more discriminating symptoms found in the elderly?
fever, acute dysuria (painful urination), new or worse urinary urgency or incontinence, gross hematuria, and suprapubic or costovertebral pain
The nurse correlates which clinical manifestations with the pathophysiology of acute pyelonephritis? A. Nausea and vomiting B. hematuria C. flank pain D. fever E. abdominal pain
A. Nausea and vomiting
B. hematuria
C. flank pain
D. fever
How to diagnose pyelonephritis
- history and physical examination
- laboratory results; urinalysis, urine culture, blood cultures, and CBC
- imaging studies: CT scan or ultrasound
Urinalysis reveals what is pyelonephritis?
can show pyuria (urine containing WBCs or pus), bacteriuria, and hematuria
-White blood cell (WBC) casts may be present
CBC reveals what in pyelonephritis?
leukocytes (WBC) increased with an increase in immature neutrophils (bands); refers to as “shift to the left”; a shift the the left indicated acute infection
Why must Urine cultures be obtained
once urinalysis is obtained and shows infection, a urine culture is conducted to identify the specific pathogen and medication sensitivities
Blood cultures are usually obtained before what?
before starting antibiotic therapy
A CT or ultrasound may reveal what?
reveal renal structures that are reduced in size or hydronephrosis, (edema or retained fluid in the kidneys) sometimes due to obstruction
Treatment for Pyelonephritis
hospitalization allowing treatment with IV antibiotics
-outpatient treatment may be acceptable for patients with mild to moderate illness and those who can be stabilized with oral antibiotics and adequate hydration and discharged under close supervision
>antibiotics
Medications used to treat pyelonephritis
antibiotics
-management depends on severity of symptoms
-treatment includes outpatient treatment with oral antibiotics or short-stay hospitalization with IV antibiotics with the possible continuation of oral antibiotics upon discharge
>broad spectrum antibiotics combined with an aminoglycoside is typically used
>Trimethoprim-sulfamethoxazole (Bactrim)
>fluoroquinolones such as ciprofloxacin (Cipro)
Trimethoprim-sulfamethoxazole (Bactrim)
antibiotic
- commonly used because of its effectiveness and low cost
- contraindicated in patients with a sulfa allergy
Fluoroquinolone: Ciprofloxacin (Cipro)
antibiotic