Week 12: Chp 58: Irritable Bowel Syndrome Flashcards
What is IBS?
complex and misunderstood functional disorder characterized by abdominal pain and altered bowel habits for which no other pathophysiological cause can be found
- characterized by areas of bowel spasm and dilation
- unknown etiology with no known cure
4 Subtypes of IBS
- IBS-C (constipation dominant)
- IBS-D (diarrhea dominant)
- IBS-M (mixed, or alternating from diarrhea to constipation)
- IBS unclassified (meets IBS diagnostic criteria but cannot be accurately categorized with the other 3)
Many theories regarding the pathophysiology
- gastrointestinal motility
- visceral hypersensitivity
- intestinal inflammation
- post-infection
- bacterial overgrowth
- food sensitivity
- carbohydrate malabsorption
- gluten sensitivity
- genetics
- psychosocial dysfunction
Clinical Manifestations
diarrhea, constipation, flatus, and abdominal pain that may vary based on classification
- often report LLQ pain accompanied by abdominal distension and alternating bouts of diarrhea and constipation
- the pain increases after eating and is relieved with bowel movements
- due to the pain and abdominal cramping, the patient may become anorexic with noticeable weight loss
Treatment for IBS
is symptom based
- no one treatment is effective for all patients; highly individualized
- may be a lifelong struggle
- patients are encouraged to keep a dietary diet, episodes of stress, and triggers associated with the onset of symptoms
How to Diagnose IBS
no test shows a definitive diagnosis of IBS
-number of tests may be performed to rule out other pathophysiological causes for concern:
>flexible sigmoidoscopy, colonoscopy, CT scans, lactose intolerance tests, stool cultures, and blood tests
-after organic causes have been ruled out, the Rome IV or Manning Criteria are used to make diagnosis of IBS
Rome IV Diagnostic Criteria for Functional Gastrointestinal Disorders
common diagnostic instruments
-patient must have had recurrent abdominal pain or discomfort at least 1 day per week in the last 3 months associated with two or more of the following:
>improvement (of pain) with defecation
>onset associated with a change in frequency of stool
>onset associated with a change in form (appearance) of stool
Manning Criteria
tool used in the diagnosis of IBS >the more clinical manifestations the patient has the greater the likelihood of being diagnosed with IBS: -pain relieved with defecation -more frequent stools at the onset of pain -looser stools at the onset of pain -visible abdominal distension -passage of mucus -sensation of incomplete evacuation
Treatment includes
- medications
- dietary modification
- complementary and alternative therapies
Medications used for treatment of IBS
- antispasmodic agents
- antidiarrheal
- guanylate cyclase agonists
- serotonergic agents
- selective type 2 chloride channel (CIC-2) activator
- antidepressants
- selective serotonin reuptake inhibitors (SSRI)
- tricyclic antidepressants (TCAs)
Medications: antispasmodic agents
anticholinergic and antimuscarinic components that block acetylcholine, relaxing smooth muscle spasm and GI motility; inhibit gastric secretion
>Dicyclomine (Bentyl, Antispas)
Medications: Anti-diarrheals
- slow bowel transit, enhance water absorption, and strengthen anal sphincter tone, resulting in fewer stools but does not relieve pain; Loperamide (Imodium)
- decreases motility, propulsion, and secretions; Diphenoxylate hydrochloride (Lomotil)
Medications: Guanylate cyclase agonists
stimulates intestinal fluid secretion and transit
>Linaclotide (Linzess) for IBS-C despite treatment with osmotic laxative
Medications: Serotonergic agents
- agonist activity causes release of other neurotransmitters and results in increased peristalsis, increased intestinal secretion, and decreased visceral sensitivity; Tegaserod (Zelnorm) for IBS-C in females
- limits gastrocolic reflexes, which can slow transit time and improve muscle tone; Alosetron (Lotronex) for refractory IBS-D in female patients
Medications: Selective type-2 chloride channel (CIC-2) activator
increases fluid secretion in the small intestine and is believed to enhance colonic motility by increasing intraluminal volume
>Lubiprostone for IBS-C in women
Medications: Anti-depressants
low doses of antidepressants have been shown to decrease pain
Medications: SSRIs
inhibit serotonin uptake and may increase pain threshold while decreasing transit time
>Paroxetine (Paxil); fluoxetine (Prozac); sertraline (Zoloft)