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Principles of Disease > Virus Pathogenesis > Flashcards

Virus Pathogenesis Flashcards

1
Q

What is an example of cell destruction following a viral infection?

A

Death of T4+ cells by HIV.

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2
Q

What is an example of virus induced changes to cellular gene expression?

A

Cellular transformation by tumour viruses.

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3
Q

What are 2 examples of immunopathogenic diseases?

A

Influenza A

Coxsackievirus

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4
Q

Name 7 sites of viral entry?

A 
Conjunctiva
Arthropod
Capillary
Skin
Respiratory Tract
Alimentary Tract
Urinogenital tract
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5
Q

What are the 2 types of disease?

A

Overt disease

Unapparent

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6
Q

What type of infection is influenza A?

A

Respiratory

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7
Q

What two types of infection are enterovirus?

A

Enteric and neurological.

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8
Q

Where are acute virus infections located?

A

Specific site of the body.

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9
Q

What is the process of the influenza A virus infection?

A

Virus infects cells of respiratory tract
Destruction of respiratory epithelium
Altered cytokine expression leading to fever

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10
Q

Define antigenic drift.

A

Gradual evolution of viruses to generate antigenic variants.

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11
Q

Define antigenic shift.

A

Significant changes in virus antigenic structure.

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12
Q

What is novel influenza virus?

A

Non human hosts for influenza A viruses play a role in generating new virus types e.g swine flu.

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13
Q

Name 5 enterovirus infections.

A 
Poliomyelitis
Aseptic meningitis
Myocarditis
Pancreatitis
Respiratory infections
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14
Q

Name an example of latent virus infections.

A

Herpes simplex

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15
Q

What is type 1 and type 2 herpes?

A

Type 1 - cold sores

Type 2 - genital lesions

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16
Q

What is the process of herpes virus?

A 
Primary infection of epithelial cells
Virus migration to ganglia
Virus latency
Stimuli reactivates virus
Virus migrates to epithelial cells leading to replication
17
Q

What are 2 examples of virus-induced tumours?

A

Papillomaviruses

Retroviruses

18
Q

What is the process of human t-lymphotropic virus?

A

Transmission by blood or mother to child
Infects T cells
modifies host cell gene expression using a transactivating protein
Directly responsible for tumour.

19
Q

What is the process of retrovirus induced tumours?

A

Virus infects cell
Viruses nucleic acid integrates into genome
Virus causes changes in cellular gene expression
Uncontrolled cell multiplication

Principles of Disease (42 decks)

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