Chronic Inflammation 2 Flashcards

1
Q

What is granulomatous inflammation characterised by?

A

Granulomas in tissues and organs.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is granulomatous inflammation stimulated by?

A

Indigestible antigen.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What do granulomas aggregate?

A

Epitheloid macrophages in tissues.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What can granulomas contain and surround?

A

Giant cells

Dead material

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What may surround granulomas?

A

Lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What type of hypersensitivity is found in granulomas?

A

4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are granulomas comprised of?

A

Macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What do giant cells contain?

A

Large cytoplasm and multiple nuclei.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Where is Langhan’s type often found?

A

Tuberculosis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What type of cytoplasm does Langhan’s type have?

A

Large eosinophilic.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are foreign body types often associated with?

A

Pyogenic granulation tissue.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How do silicone associated granulomas occur?

A

Ruptured silicone implants.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the featur of Warthin-Finkeldy type granulomas?

A

Central cluster of nuclei.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What three infections are granulomatous diseases?

A

Tuberculosis
Leprosy
Syphilis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What infection is caseous necrosis associated with?

A

Tuberculosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is caseous necrosis?

A

Dead tissue surrounded by macrophages, giant cells and lymphocytes.

17
Q

What is syphilitic gumma?

A

Non-cancerous growth.

18
Q

What are three examples of non-infectious granulomas?

A

Rheumatoid disease
Sarcoidosis
Crohn’s disease

19
Q

What is wound healing?

A

Process of repair of tissue damage.

20
Q

What is wound healing a phase of?

A

Acute inflammation

21
Q

What type of tissue is formed during wound healing?

A

Granulation

22
Q

What is local angiogenesis?

A

New vessels growing

23
Q

Surgical wound healing is healing by ______ intention.

A

Primary

24
Q

In surgical wound healing, why is a minimal gap left?

A

To aid blood clotting.

25
Q

What type of scar is left in surgical wound healing?

A

Small linear

26
Q

Healing of larger defects heal by ______ intention.

A

Secondary.

27
Q

Which type of healing has lots of granulation tissue?

A

Larger defect

28
Q

What are the 7 steps of healing?

A

Injury causes blood clot and acute inflammation.
Growth factors and cytokines involve
Granulation tissue grows
Phagocytosis of fibrin
Myofibroblasts move in and lay down collagen
Contraction of scar
Re-epithelialisation

29
Q

What are good conditions for wound healing?

A
Clean
No haematoma
Sound nutrition
Metabolic stability and normality 
Normal inflammation
Local mediators
30
Q

What are bad conditions for wound healing?

A
Dirty 
Poorly nourished
Lacking Vit C and A
Abnormal CHO metabolism
Inhibition of aniogenesis
31
Q

Fracture healing has to repair ______ structure as well as ______ tissue.

A

Bony

Soft

32
Q

What does granulation tissue contain as well as fibroblasts?

A

Osteoblasts

33
Q

What is the 3 step process of callus formation?

A

Osteoblasts lay down woven bone
Nodules of cartilage
Bone remodelling