Chronic Inflammation 2 Flashcards
What is granulomatous inflammation characterised by?
Granulomas in tissues and organs.
What is granulomatous inflammation stimulated by?
Indigestible antigen.
What do granulomas aggregate?
Epitheloid macrophages in tissues.
What can granulomas contain and surround?
Giant cells
Dead material
What may surround granulomas?
Lymphocytes
What type of hypersensitivity is found in granulomas?
4
What are granulomas comprised of?
Macrophages
What do giant cells contain?
Large cytoplasm and multiple nuclei.
Where is Langhan’s type often found?
Tuberculosis.
What type of cytoplasm does Langhan’s type have?
Large eosinophilic.
What are foreign body types often associated with?
Pyogenic granulation tissue.
How do silicone associated granulomas occur?
Ruptured silicone implants.
What is the featur of Warthin-Finkeldy type granulomas?
Central cluster of nuclei.
What three infections are granulomatous diseases?
Tuberculosis
Leprosy
Syphilis
What infection is caseous necrosis associated with?
Tuberculosis
What is caseous necrosis?
Dead tissue surrounded by macrophages, giant cells and lymphocytes.
What is syphilitic gumma?
Non-cancerous growth.
What are three examples of non-infectious granulomas?
Rheumatoid disease
Sarcoidosis
Crohn’s disease
What is wound healing?
Process of repair of tissue damage.
What is wound healing a phase of?
Acute inflammation
What type of tissue is formed during wound healing?
Granulation
What is local angiogenesis?
New vessels growing
Surgical wound healing is healing by ______ intention.
Primary
In surgical wound healing, why is a minimal gap left?
To aid blood clotting.
What type of scar is left in surgical wound healing?
Small linear
Healing of larger defects heal by ______ intention.
Secondary.
Which type of healing has lots of granulation tissue?
Larger defect
What are the 7 steps of healing?
Injury causes blood clot and acute inflammation.
Growth factors and cytokines involve
Granulation tissue grows
Phagocytosis of fibrin
Myofibroblasts move in and lay down collagen
Contraction of scar
Re-epithelialisation
What are good conditions for wound healing?
Clean No haematoma Sound nutrition Metabolic stability and normality Normal inflammation Local mediators
What are bad conditions for wound healing?
Dirty Poorly nourished Lacking Vit C and A Abnormal CHO metabolism Inhibition of aniogenesis
Fracture healing has to repair ______ structure as well as ______ tissue.
Bony
Soft
What does granulation tissue contain as well as fibroblasts?
Osteoblasts
What is the 3 step process of callus formation?
Osteoblasts lay down woven bone
Nodules of cartilage
Bone remodelling
