Chronic Inflammation 2

Question 1

What is granulomatous inflammation characterised by?

Answer 1

Granulomas in tissues and organs.

Question 2

What is granulomatous inflammation stimulated by?

Answer 2

Indigestible antigen.

Question 3

What do granulomas aggregate?

Answer 3

Epitheloid macrophages in tissues.

Question 4

What can granulomas contain and surround?

Answer 4

Giant cells

Dead material

Question 5

What may surround granulomas?

Answer 5

Lymphocytes

Question 6

What type of hypersensitivity is found in granulomas?

Answer 6

4

Question 7

What are granulomas comprised of?

Answer 7

Macrophages

Question 8

What do giant cells contain?

Answer 8

Large cytoplasm and multiple nuclei.

Question 9

Where is Langhan’s type often found?

Answer 9

Tuberculosis.

Question 10

What type of cytoplasm does Langhan’s type have?

Answer 10

Large eosinophilic.

Question 11

What are foreign body types often associated with?

Answer 11

Pyogenic granulation tissue.

Question 12

How do silicone associated granulomas occur?

Answer 12

Ruptured silicone implants.

Question 13

What is the featur of Warthin-Finkeldy type granulomas?

Answer 13

Central cluster of nuclei.

Question 14

What three infections are granulomatous diseases?

Answer 14

Tuberculosis
Leprosy
Syphilis

Question 15

What infection is caseous necrosis associated with?

Answer 15

Tuberculosis

Question 16

What is caseous necrosis?

Answer 16

Dead tissue surrounded by macrophages, giant cells and lymphocytes.

Question 17

What is syphilitic gumma?

Answer 17

Non-cancerous growth.

Question 18

What are three examples of non-infectious granulomas?

Answer 18

Rheumatoid disease
Sarcoidosis
Crohn’s disease

Question 19

What is wound healing?

Answer 19

Process of repair of tissue damage.

Question 20

What is wound healing a phase of?

Answer 20

Acute inflammation

Question 21

What type of tissue is formed during wound healing?

Answer 21

Granulation

Question 22

What is local angiogenesis?

Answer 22

New vessels growing

Question 23

Surgical wound healing is healing by ______ intention.

Answer 23

Primary

Question 24

In surgical wound healing, why is a minimal gap left?

Answer 24

To aid blood clotting.

Question 25

What type of scar is left in surgical wound healing?

Answer 25

Small linear

Question 26

Healing of larger defects heal by ______ intention.

Answer 26

Secondary.

Question 27

Which type of healing has lots of granulation tissue?

Answer 27

Larger defect

Question 28

What are the 7 steps of healing?

Answer 28

Injury causes blood clot and acute inflammation. Growth factors and cytokines involve Granulation tissue grows Phagocytosis of fibrin Myofibroblasts move in and lay down collagen Contraction of scar Re-epithelialisation

Question 29

What are good conditions for wound healing?

Answer 29

``` Clean No haematoma Sound nutrition Metabolic stability and normality Normal inflammation Local mediators ```

Question 30

What are bad conditions for wound healing?

Answer 30

``` Dirty Poorly nourished Lacking Vit C and A Abnormal CHO metabolism Inhibition of aniogenesis ```

Question 31

Fracture healing has to repair ______ structure as well as ______ tissue.

Answer 31

Bony | Soft

Question 32

What does granulation tissue contain as well as fibroblasts?

Answer 32

Osteoblasts

Question 33

What is the 3 step process of callus formation?

Answer 33

Osteoblasts lay down woven bone Nodules of cartilage Bone remodelling