VI-Pancreas

Question 1

acinar cell function

Answer 1

secrete digestive enzymes and fluid
protein synthesis

Question 2

duct cells function

Answer 2

secrete bicarb
transport ions and fluid

Question 3

goblet cell function

Answer 3

secrete mucin for lubrication, hydration, protection, immune resp

Question 4

primary stimuli of acinar cells

Answer 4

1. Ach
2. CCK

Question 5

trypsinogen function

Answer 5

protein digestion

Question 6

enzymes secreted in active state

Answer 6

1. alpha amylase for carbs
2. lipase for lipids
3. RNase for nucleotides

Question 7

how zymogens are stored

Answer 7

stored inactively in vesicles with trypsin inhibitors and low pH

Question 8

function of enteropeptidase

Answer 8

convert/cleave trypsinogen into trypsin to activate other enzymes

Question 9

targets of secretin

Answer 9

1. inc release of somatostatin
2. dec gastrin secretion
3. dec proton pump expression
4. stim pancreatic duct to syn bicarb

Question 10

phases of pancreatic secretion

Answer 10

1. cephalic
2. gastric
3. intestinal

Question 11

cephalic phase stim by

Answer 11

sight/smell/taste/mastication
regulated by vagal pathways

Question 12

gastric phase stim

Answer 12

distension, gastrin, peptides
reg by vagal/gastrin

Question 13

intestinal phase stim

Answer 13

amino acids, fatty acids, H+
reg by CCK, secretin, enteropancreatic reflexes
-lipids/FAs are primary regulator to induce CCK

Question 14

interdigestive period parallels

Answer 14

MMC so secretions from pancreas highest during intestinal contractility

Question 15

phases of pancreatitis

Answer 15

1. inital - intrapancreative digestive enzymes activated and damage acinar cells
2. intrapancreatic inflamm
3. proteolytic enzymes and cytokines effect distant organs