VI-Calcium and Bone Flashcards
acidemia =
hypercalcemia so inc ionized Ca
alkalemia =
hypocalcemia so dec ionized Ca
inc plasma anions =
more Ca forms complexes so dec ionized Ca
-i.e. phosphate
hypercalcemia presentation
- muscle weakness
- lethargy
- depression
- constipation
- reduced appetite
- heartburn, nausea
- polyurea
- nephrolithiasis aka kidney stones
- cardiac dysrhythmia
hypocalcemia presentaiton
- muscle spasms from inc neuromuscluar excitabilty
- tingling and numbness
- hypocalcemic tetany
- seizures
- cardic dysrhythmias
- trousseau sign of claw hand
- chovostek sign of twitching with facial N
dec plasma Ca = ? PTH
inc PTH to inc plasma Ca
-inc bone resoprtion/break down
-dec phosphate reabsorption
-inc Ca absorption
effects of PTH
- dec plasma phosphate
- inc plasma Ca
- inc calcitriol/active vit D
stimulants of PTH
- low plasma Ca
- high plasma phosphate
inhibits PTH
- high plasma Ca
- high calcitriol
- low plasma P
effects of calcitriol
- inc P and Ca reabsorption from kidney and intestine
- promote PTH action from bone
aka want to inc Ca and P
stimulate calcitirol
- PTH
- low plasma P
inhibit calcitriol
- high plasma Ca
- high plasma P
- high calcitriol
1alpha-hydroxylase function
convert vitamin D precursor to active calcitriol
-inhibited by FGF23 from osteoblasts
hypoparathyroidism
insufficient secretion of PTH from PT glands
-from surgery, autoimmune, familial, idiopathic
primary hyperparathyroidism
xs PTH from dysfunction of PT gland
-usually adenoma