VI- GI Protozoa Flashcards

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1
Q

amebiasis etiology

A

aka amebic dysentery
from entamoeba histolytica (cyst form)

fecal oral in food/water

travelers

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2
Q

amebiasis presentations

A
  1. mostly asymptomatic if stay in lumen of intestine, shed cysts
  2. intestinal dz if invade colon tissue aka dysentery, fever rare, shed trophs (less infectious)
  3. extraintestinal if get into circulation, esp hepatic problems
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3
Q

entamoeba histolytica histology

A

-flask shaped lesions in intestinal wall by trophozoites

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4
Q

entamoeba histolytica diagnosis

A
  1. stool exam or antigen detection if intestinal
  2. biopsy and serology if extraintestinal
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5
Q

giardiasis etiology

A

giardia lamblia- flagellated

fecal contaminated water, daycares with cysts
-kids in summer and care givers

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6
Q

giardiasis pathology

A

attach to small intestine wall NOT invade tissue

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7
Q

giardia histology

A

trophozoite form = teardrop shaped with suction cup/vental disk for adherence, 2 nuclei
look like stingrays

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8
Q

giardia presentation

A

sudden onset of:
foul smelling greasy stools bc passing a lot of fat + other non specific
NO BLOOD since no tissue invasion

if turns chronic risk malnutrition

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9
Q

giardia diagnosis

A

observe cysts or trophs in stool
-fecal antigen detection newer

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10
Q

balantidiasis etiology

A

balantidium coli - ciliated
fecal oral associated with pigs

very rare

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11
Q

balantidiasis presentation

A
  1. usually asymp
  2. chronic - diarrhea or constipation
  3. acute invasion- dysentery
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12
Q

cryptosporidiosis etiology

A

cryptosporidium parvum
-replicate within intestinal epithelial cells, not making lesions/invasive

associated with cow manuer, daycares, pools/lakes

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13
Q

cryptosporidiosis histology

A

oocyst (from sexual reprod instead of asex) on modified acid fast stain

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14
Q

cryptosporidiosis presentation

A

watery diarrhea no blood
-kids in summer, HIV/AIDS high risk

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15
Q

cyclosporiasis etiology

A

cyclospora cayetanensis
-associate with food borne outbreaks fresh fruits and veggies RASPBERRIES

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16
Q

cyclosporiasis histology

A

acid fast oocysts + fluorescent under UV light (differentiate b/t cryptosporidium)

17
Q

cyclosporiasis presentation

A

watery profuse diarrhea
-cramping, fatigue, weight loss

AIDS high risk

18
Q

isosporiasis etiology

A

from isospora/cystoisospora belli

19
Q

isospora histology

A

enlongated shape on acid fast
fluorescent under UV

20
Q

isosporiasis presentation

A

fever + watery diarrhea + weight loss
severe in AIDS

21
Q

microsporidiosis

A

obligate intracellular parasites
-infect by ingestion of spores

intestinal disease or disseminate esp AIDS

22
Q

treating protozoa

A

anti-protozoal compounds target:
-energy production
-nucleic acid syn
-protein syn
-metabolic pathways

23
Q

nitazoxanide

A

interfere with energy metabolism of cryptosporidium

24
Q

sulfonamide

A

interfere with folic acid syn of cyclospora and isospora