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Pharm 203 > Vasoactive facts > Flashcards

Vasoactive facts Flashcards

1
Q

MLCK

A

myosin light chain kinase
in SMC
activated by Ca+ to cause contraction

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2
Q

MLCP

A

myosin light chain phosphatase, dephosphorylates MLC to stop contraction

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3
Q

Increasing cAMP

A

activates MLCP and promotes Ca+ efflux, causing relaxation

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4
Q

increasing cGMP

A

activates MLCP and opposes Ca+ influx

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5
Q

Major vasodilators endogenous

A

-NO
-prostanoids (PGI2)
-EDHF endothelium derived hyper polarizing factor
-CNP C- natriuretic peptide

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6
Q

major vasoconstrictors

A

Endothelin
TXA2
Angiotensin 2

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7
Q

endothelin

A

ET-1 produced from damage (local mediator)
causes constriction via IP3 mediated Ca+ release

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8
Q

ACE

A

angiotensin converting enzyme from 1->2
also cleaves bradykinin to inactive form

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9
Q
A
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Pharm 203 (38 decks)

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