anti depressants drugs

Question 1

escitalopram

Answer 1

SSRI
-has H1 blockade
—
-anti depressant
—
nausea
headache
serotonin side effects

Question 2

Paroxetine

Answer 2

SSRI
-also favours NE
—
-anti depressant
—
nausea
headache
serotonin side effects

Question 3

Sertaline

Answer 3

SSRI
-also favours DA
—
-anti depressant
—
nausea
headache
serotonin side effects

Question 4

Vortioxetine

Answer 4

SSRI
-also 5-HT agonist and antagonist
—
-anti depressant
—
less sedation, insomnia and weight gain

Question 5

amitriptyline

Answer 5

TCAs
-balanced NE and 5-HT
—
-anti depressant
—
sedation
motor incoordination
-anti cholinergic

Question 6

Desipramine

Answer 6

TCAs
-more NE block than 5-HT
—
-anti depressant
—
sedation
motor incoordination
-anti cholinergic

Question 7

Venlafaxine

Answer 7

SNRI
-5HT at low dose
-NE at high dose
-similar to TCA but less off target blocks
—
anti-depressant

Question 8

Bupropion

Answer 8

NDRI
-NET and DAT inhibitor
-nAChR block
—-
anti depressant
smoking cessation
—-

Question 9

Trazodone

Answer 9

SARI
-Blocks 5-HT 2A/2C
-Sert inhibitor
—
antidepressant
—
hypotension (alpha 1)
sedation (H1)

Question 10

Mirtazapine

Answer 10

NaSSA
-block inhibitory NE and 5-HT receptors increasing release
-H1 block
—-
antidepressant
—
no anticholinergic
less serotonin side effects

Question 11

Phenelzine

Answer 11

/
irreversible non selective MAO inhibition
—
anti depressant
—
-No MAO in gut lets active sympathomimetic drugs through causing hypertension

Question 12

Tranylcypromine

Answer 12

/
irreversible non selective MAO inhibition
—
anti depressant
—
-No MAO in gut lets active sympathomimetic drugs through causing hypertension

Question 13

Moclobemide

Answer 13

/
reversible MAO-A inhibitor
—
-anti depressant