Pulmonary hypertension drugs

Question 1

Bosentan

Answer 1

ETa antagonist
-blocks endothelin causing vasodilation
—
pulmonary hypertension
—
-headache
-flushing
-edema
-teratogenic

Question 2

Epoprostenol

Answer 2

prostacyclin analogue
-Binds IP receptors to increase cAMP
-vasodilation specifically in lung arteries
—-
-pulmonary hypertension
—
-headache
-diarrhea

Question 3

Riociguat

Answer 3

sGC activator
-allosteric activator of sGC increases cGMP
-potentiates NO action
—-
-pulmonary hypertension
—
-hypotension

Question 4

sildenafil

Answer 4

PDE5 inhibitor
-prevents cGMP breakdown
-potentiates NOs
—-
-pulmonary hypertension
—
-headache
-don’t take with NO drugs
-Erection

Question 5

Inhaled NO

Answer 5

/
not for adults only for testing
—-
in babies can help stimulate lungs switching to low pressure system instead of high