Local anesthetics

Question 1

Local anesthetic

Answer 1

blocks all local sensation

Question 2

local anesthetic admin

Answer 2

-topically for superficial pain
-Peripheral nerve block
inject hear nerve trunk can be spine
-Bierblock, isolate limb blood flow and inject distal

Question 3

local anesthetic structure

Answer 3

contain aromatic residue, ester and basic amine except benzocaine

Question 4

Local anaesthetic action

Answer 4

Binds to Inactivated Na+ channels. Becomes uncharged to enter membrane then enters from inside of cell or diffuse right into channel

Question 5

local anaesthetic advantages

Answer 5

pain nerves are thin and fire quickly meaning they are inactivated and can be bound

Question 6

local anaesthetic disadvantages

Answer 6

Tissue damages lowers pH reducing chance of being uncharged

Question 7

local anaesthetic side effects

Answer 7

Na+ inhibition in heart
Vasodilator->hypotension
sleepiness, convulsions, and CNS depression at high dose