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Pharm 203 > Cannabinoids > Flashcards

Cannabinoids Flashcards

1
Q

Eicosanoid synthesis

A

from fatty acid precursors like arachidonic acid or other 20 Carbon chains

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2
Q

Prostanoids types

A

prostaglandins
thromboxanes

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3
Q

leukotrienes

A

type of eicosanoid

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4
Q

Lipooxygenases

A

produce leukotrienes from arachidonic acid

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5
Q

COX 2

A

inducible from of COX found on immune cells

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6
Q

epoxygenases /P450

A

enzymes that produce epoxyeicosatrienoic acids from arachidonic acid

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7
Q

PGH2

A

Common prostaglandin from COX enzymes that differentiates to other forms

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8
Q

PGI2

A

Prostacyclin
-main anti clotting factor in body produced by endothelial cells
-vaso dilator

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9
Q

TXA2

A

Thromboxane
-produced in platelets it’s a pro clotting factor and vasoconstrictor

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10
Q

PGD2

A

prostanoid
-vasodilation
-inhibits clotting
-relaxes GI/Uterus

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11
Q

PGE2

A

Main inflammatory prostanoid
-vasodilation
-pyrogenic
-lung and GI SM effects (receptor dependant)

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12
Q

PGF2 alpha

A

Prostanoid
-uterine contraction

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13
Q

LTB4

A

leukotriene receptor
-pro inflammatory
-chemotaxis
-proliferation
-cytokine production

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14
Q

CysLT

A

leukotriene receptor
-contracts bronchial muscle
-vasodilation
-coronary constriction

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15
Q

THC subjective effects

A

-Relaxation
-sharpened senses
-psychoimetic effects

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16
Q

THC Objective effects

A

-Impaired memory
-imparied motor control
-catalepsy
-analgesia
-antiemetic
-increase appetite

17
Q

THC peripheral effects

A

-Vasodilation (in eye, blood shot)
-decrease eye pressure
-bronchodilation

18
Q

CB1 receptor

A

Gi/o linked causing hyperpolization (inhibit Ca2+, activate K+ channels)
-Pre synaptic and prevent NT release
-found in endothelial cells, adipocytes, peripheral fevers

19
Q

CB2 receptor

A

Gi/o linked
found on immune cells

20
Q

Endocannabionoid action

A

act as retrograde transmitters to stop activation (released from post synaptic neuron acting on pre synaptic CB1 receptors)

Pharm 203 (38 decks)

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