Cannabinoids Flashcards
Eicosanoid synthesis
from fatty acid precursors like arachidonic acid or other 20 Carbon chains
Prostanoids types
prostaglandins
thromboxanes
leukotrienes
type of eicosanoid
Lipooxygenases
produce leukotrienes from arachidonic acid
COX 2
inducible from of COX found on immune cells
epoxygenases /P450
enzymes that produce epoxyeicosatrienoic acids from arachidonic acid
PGH2
Common prostaglandin from COX enzymes that differentiates to other forms
PGI2
Prostacyclin
-main anti clotting factor in body produced by endothelial cells
-vaso dilator
TXA2
Thromboxane
-produced in platelets it’s a pro clotting factor and vasoconstrictor
PGD2
prostanoid
-vasodilation
-inhibits clotting
-relaxes GI/Uterus
PGE2
Main inflammatory prostanoid
-vasodilation
-pyrogenic
-lung and GI SM effects (receptor dependant)
PGF2 alpha
Prostanoid
-uterine contraction
LTB4
leukotriene receptor
-pro inflammatory
-chemotaxis
-proliferation
-cytokine production
CysLT
leukotriene receptor
-contracts bronchial muscle
-vasodilation
-coronary constriction
THC subjective effects
-Relaxation
-sharpened senses
-psychoimetic effects
THC Objective effects
-Impaired memory
-imparied motor control
-catalepsy
-analgesia
-antiemetic
-increase appetite
THC peripheral effects
-Vasodilation (in eye, blood shot)
-decrease eye pressure
-bronchodilation
CB1 receptor
Gi/o linked causing hyperpolization (inhibit Ca2+, activate K+ channels)
-Pre synaptic and prevent NT release
-found in endothelial cells, adipocytes, peripheral fevers
CB2 receptor
Gi/o linked
found on immune cells
Endocannabionoid action
act as retrograde transmitters to stop activation (released from post synaptic neuron acting on pre synaptic CB1 receptors)
