Amino acid drugs

Question 1

Glutamate

Answer 1

found throughout the brain as main excitatory NT
derived from Kerbs cycle

Question 2

Aspartate

Answer 2

similar to glutamate but found in more specific areas

Question 3

NMDA

Answer 3

Ionotropic glutamate channels for Ca+/Na+
activation requires glycine
4 subunits with 16 subtypes

Question 4

AMPA

Answer 4

Ionotropic glutamte channels, fast acting short lasting depolarization faster than NMDA
8 Subunits with 3 subgroups

Question 5

GABA

Answer 5

Main inhibitory transmitter, acts on all neurons in brain make up 20% of all neurons

Question 6

GABAa

Answer 6

ionotropic mostly postsynaptic for inhibition via Cl-

Question 7

GABAb

Answer 7

dimeric GPCR Gi linked inhibiting AC and opening K+ channels

Question 8

Glycine

Answer 8

important inhibitory effect in spine and brain stem
pentameric structure

Question 9

Dopamine

Answer 9

distribution is wide but not everywhere, lots on striatum (movement)

Question 10

D1 receptors

Answer 10

Gs GPCR mainly postsynaptic

Question 11

D2 receptors

Answer 11

Gi GPCR pre and post synaptic inhibition

Question 12

Nigrostriatal pathways

Answer 12

dopamine motor control

Question 13

Mesocortical/mesolimbic

Answer 13

dopamine reward and emotion pathway

Question 14

tuberohypophyseal pathway

Answer 14

dopamine prolactin function